PMC:4307189 / 32729-37229 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4307189","sourcedb":"PMC","sourceid":"4307189","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4307189","text":"Table 2 Description of top 50 (based on sorted Odds ratio) cross-talks among all 168 potential drug-resistant cross-talks between EGFR/ErbB signaling and other pathways from all the analyses using Reactome, KEGG and WikiPathway databases in GSE38376\ngene i ::gene j EGFR/ErbB :: PrYijR=1 PrYijP=1 Odds ratio Avg GEiP : Avg GEiR :\nSignaling pathway j Avg GEjP Avg GEjR\nAKT2::MAML2 §,¶ Notch signaling 0.5 0.03 16.67 87.71::76.59 96.84::78.6\nMDM2::APC §,$ Wnt signaling 0.5 0.03 16.67 76.33::82.43 77.9::86.76\nKIT::CDC73 § Wnt signaling 0.5 0.03 16.67 82.14::104.01 82.68::110.88\nMDM2::CDC73 § Wnt signaling 0.5 0.03 16.67 76.33::104.01 77.9::110.88\nKIT::GNAQ § GPCR signaling 0.5 0.03 16.67 82.14::130 82.68::139.33\nMDM2::GNAQ §,$ GPCR signaling 0.5 0.03 16.67 76.33::130 77.9::139.33\nKIT::TSHR § GPCR signaling 0.5 0.03 16.67 82.14::71.32 82.68::71.66\nMDM2::TSHR § GPCR signaling 0.5 0.03 16.67 76.33::71.32 77.9::71.66\nAKT2::APC ¶ Wnt signaling 0.5 0.03 16.67 87.71::82.43 96.84::86.76\nAKT2::APC ¶ Hippo signaling 0.5 0.03 16.67 87.71::82.43 96.84::86.76\nAKT2::CDH1 ¶ Hippo signaling 0.5 0.03 16.67 87.71::74.2 96.84::79.8\nAKT2::GNAQ ¶ Gnrh signaling 0.5 0.03 16.67 87.71::130 96.84::139.33\nAKT2::GNAQ ¶ Calcium signaling 0.5 0.03 16.67 87.71::130 96.84::139.33\nAKT2::MDM2 ¶ p53 signaling 0.5 0.03 16.67 87.71::76.33 96.84::77.9\nMDM2::AKT2 $ Regulation of toll-like 0.5 0.03 16.67 76.33::87.71 77.9::96.84\nreceptor signaling\nMDM2::AKT2 $ insulin signaling 0.5 0.03 16.67 76.33::87.71 77.9::96.84\nMDM2::AKT2 $ RANKL/RANK signaling 0.5 0.03 16.67 76.33::87.71 77.9::96.84\nMDM2::AKT2 $ AMPK signaling 0.5 0.03 16.67 76.33::87.71 77.9::96.84\nMDM2::AKT2 $ MAPK signaling 0.5 0.03 16.67 76.33::87.71 77.9::96.84\nMDM2::AKT2 $ Tweak signaling 0.5 0.03 16.67 76.33::87.71 77.9::96.84\nMDM2::AKT2 $ Toll-like 0.5 0.03 16.67 76.33::87.71 77.9::96.84\nreceptor signaling\nMDM2::APC $ BDNF signaling 0.5 0.03 16.67 76.33::82.43 77.9::86.76\nMDM2::APC $ Wnt signaling Netpath 0.5 0.03 16.67 76.33::82.43 77.9::86.76\nMDM2::APC $ Wnt signaling 0.5 0.03 16.67 76.33::82.43 77.9::86.76\nand Pluripotency\nMDM2::COL1A1 $ Nanoparticle-mediated 0.5 0.03 16.67 76.33::91.44 77.9::102.54\nactivation of receptor\nsignaling\nMDM2::COL1A1 $ Osteoblast signaling 0.5 0.03 16.67 76.33::91.44 77.9::102.54\nMDM2::GNAQ $ TSH signaling 0.5 0.03 16.67 76.33::130 77.9::139.33\nMDM2::GNAQ $ Serotonin Receptor 2 0.5 0.03 16.67 76.33::130 77.9::139.33\nand STAT3 signaling\nMDM2::GNAQ $ Serotonin Receptor 2 0.5 0.03 16.67 76.33::130 77.9::139.33\nand ELK-SRF/GATA4\nsignaling\nMDM2::ITK $ T-Cell Receptor and 0.5 0.03 16.67 76.33::89.86 77.9::93.27\nCo-stimulatory signaling\nMDM2::ITK $ Tcr signaling 0.5 0.03 16.67 76.33::89.86 77.9::93.27\nMDM2::KIT $ Kit receptor signaling 0.5 0.03 16.67 76.33::82.14 77.9::82.68\nMDM2::PAX5 $ ID signaling 0.5 0.03 16.67 76.33::68.91 77.9::71.02\nMDM2::TSHR $ TSH signaling 0.5 0.03 16.67 76.33::71.32 77.9::71.66\nAKT2::TP53 § Notch signaling 0.5 0.04 12.5 87.71::128.73 96.84::155.09\nKIT::APC § Wnt signaling 0.5 0.04 12.5 82.14::82.43 82.68::86.76\nKIT::MAML2 § Notch signaling 0.5 0.04 12.5 82.14::76.59 82.68::78.6\nKIT::STK11 § IGF1R signaling 0.5 0.04 12.5 82.14::71.97 82.68::74.95\nKIT::STK11 § insulin receptor signaling 0.5 0.04 12.5 82.14::71.97 82.68::74.95\nKIT::TP53 § Notch signaling 0.5 0.04 12.5 82.14::128.73 82.68::155.09\nMDM2::MAML2 §,$ Notch signaling 0.5 0.04 12.5 76.33::76.59 77.9::78.6\nMDM2::STK11 § IGF1R signaling 0.5 0.04 12.5 76.33::71.97 77.9::74.95\nMDM2::STK11 § insulin receptor signaling 0.5 0.04 12.5 76.33::71.97 77.9::74.95\nMDM2::TP53 § Notch signaling 0.5 0.04 12.5 76.33::128.73 77.9::155.09\nAKT2::GNAS ¶ Gnrh signaling 0.5 0.04 12.5 87.71::5465.46 96.84::6212.43\nAKT2::GNAS ¶ Calcium signaling 0.5 0.04 12.5 87.71::5465.46 96.84::6212.43\nAKT2::NF2 ¶ Hippo signaling 0.5 0.04 12.5 87.71::85.75 96.84::87.36\nAKT2::TP53 ¶ P53 signaling 0.5 0.04 12.5 87.71::128.73 96.84::155.09\nAKT2::TP53 ¶ Wnt signaling 0.5 0.04 12.5 87.71::128.73 96.84::155.09\nCBL::CDH1 ¶ RAP1 signaling 0.5 0.04 12.5 194.46::74.2 208.45::79.8\nCross-talks found using signaling pathways from §Reactome, ¶KEGG, and $xx−xxWikiPathway Databases; Pathway j is the pathway containing gene j; PrYijR=1 and PrYijP=1 are the posterior probabilities of gene i:gene j in Resistant and Parental networks, respectively; AvgGEiP is the average GE value of all Parental conditions (each of which is an average of 3 samples) for gene i, AvgGEiR is similar but with Resistant conditions, and others are likewise 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