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Next, for each edge we calculated the odds ratio of their posterior probabilities as defined above. The rationale behind this calculation was that the edges (gene-pairs) found with high probabilities in resistant conditions but lower probabilities in parental conditions are more likely to be due to acquired resistance in cell lines. Therefore, we chose only gene-pairs with high odds ratio (≥ 10.0) and high posterior probabilities (≥ 0.5) of occurring in resistant conditions. We found 11,515 such gene-pairs (Additional file 2: Table S1) among all 68,265 [=(370×369)÷2] possibilities.