PMC:4307189 / 21560-22385 JSONTXT

{"project":"2_test","denotations":[{"id":"25599599-18434343-14868125","span":{"begin":331,"end":333},"obj":"18434343"},{"id":"25599599-24243840-14868126","span":{"begin":531,"end":533},"obj":"24243840"},{"id":"25599599-12539951-14868127","span":{"begin":596,"end":598},"obj":"12539951"},{"id":"25599599-22096230-14868128","span":{"begin":675,"end":677},"obj":"22096230"}],"text":"Since, Lapatinib is an EGFR and ErbB inhibitor, we considered the cross-talks between the EGFR/ErbB signaling pathway and other signaling pathways. Here cross-talks can be defined as any gene-pair (genei,genej) in which genei ∈ {genes in EGFR/ErbB signaling pathway} and genej ∈ {genes in other signaling pathways}, or vice versa [31]. Thus if both genes in any gene-pair were found in the same signaling pathway, that particular gene-pair was trivially ignored. For that purpose, we collected 24 signaling pathways from Reactome [32] (downloaded at 19/05/2014), 35 signaling pathways from KEGG [33,34] (downloaded at 21/10/2014), and 63 signaling pathways from WikiPathway [35] (downloaded at 16/10/2014) databases. Each signaling pathway downloaded from these databases was encoded as tab-delimitated lists of gene symbols."}