PMC:4289681 / 37664-38957 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4289681","sourcedb":"PMC","sourceid":"4289681","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4289681","text":"Bosch et al.6 analyzed mtDNA and Y chromosome DNA from 69 Inuit and demonstrated that the mtDNA, which is maternally inherited, was exclusively of Inuit origin, whereas more than 50% of the Y chromosomes, which are paternally inherited, were of European origin.6 However, their study was based on a small number of individuals from a limited number of locations in Greenland. To more broadly assess and quantify the sex bias in the European gene flow, we estimated the amount of mtDNA of European origin in our much larger full data set. We distinguished between European and Inuit mtDNA by using a single diagnostic mtDNA SNP: the MT1736 marker that defines the A haplogroup. This marker perfectly separates the two populations for all unadmixed individuals (Table S2), and we used it to obtain estimates of the amount of mtDNA of European origin shown in Figure S6. We found that although the mtDNA in Greenland is not exclusively Inuit, the amount of European female ancestry based on mtDNA is only ∼1.0%. This is about 25 times lower than the proportion of autosomal DNA of European origin. The large discrepancy between admixture proportions at autosomal and mtDNA markers is in line with the results of Bosch et al.,6 who concluded that 50% of the male ancestry in Greenland is European.","tracks":[{"project":"2_test","denotations":[{"id":"25557782-12594533-2052287","span":{"begin":12,"end":13},"obj":"12594533"},{"id":"25557782-12594533-2052288","span":{"begin":261,"end":262},"obj":"12594533"},{"id":"25557782-12594533-2052289","span":{"begin":1222,"end":1223},"obj":"12594533"}],"attributes":[{"subj":"25557782-12594533-2052287","pred":"source","obj":"2_test"},{"subj":"25557782-12594533-2052288","pred":"source","obj":"2_test"},{"subj":"25557782-12594533-2052289","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#e0ec93","default":true}]}]}}