PMC:4289553 / 5061-6716 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4289553","sourcedb":"PMC","sourceid":"4289553","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4289553","text":"Patients\nWe performed a simulation study, based on three patient cohorts.\nThe first cohort consisted of patients with head and neck cancer who were followed during 15 years for survival (“HNSCC cohort”) [18]. The cohort contained 7 predictor variables (2 dichotomous, 4 categorical and 1 continuous) and a dichotomous (0/1) outcome with an incidence of 601/1282 (46.9%) (Table 1).\nTable 1 Cohort characteristics\nCohort\nHNSCC TBI CHIP\nOutcome 5 year survival 6 months mortality Intracranial findings\nType dichotomous dichotomous dichotomous\nEvent/total 601/1282 (46.9%) 386/1731 (22.3%) 243/3181 (7.6%)\nPredictors 2 dichotomous 4 dichotomous 9 dichotomous\n4 categorial 1 categorial 1 categorial\n1 continuous 4 continuous 2 continuous\nThe second cohort consisted of patients with traumatic brain injury (“TBI cohort”) [19]. The cohort contained 10 predictor variables (4 dichotomous, 1 categorical and 4 continuous) and a dichotomous outcome with an incidence of 386/1731 (22.3%) (Table 1).\nThe third cohort consisted of patients suspected of head injury who underwent a CT-scan (“CHIP cohort”) [6]. This cohort contained 12 predictor variables (9 dichotomous, 1 categorical and 2 continuous) and a dichotomous (0/1) outcome with an incidence of 243/3181 (7.6%) (Table 1).\nWe generated artificial cohorts by replicating the HNSCC cohort 20 times, the TBI cohort 10 times and the CHIP cohort 6 times. This resulted in an artificial cohort consisting of 25,640 subjects (“HNSCC artificial cohort”), an artificial cohort consisting of 17,310 subjects (“TBI artificial cohort”) and an artificial cohort consisting of 19,086 subjects (“CHIP artificial cohort”).","divisions":[{"label":"title","span":{"begin":0,"end":8}},{"label":"p","span":{"begin":9,"end":73}},{"label":"p","span":{"begin":74,"end":733}},{"label":"table-wrap","span":{"begin":381,"end":733}},{"label":"label","span":{"begin":381,"end":388}},{"label":"caption","span":{"begin":389,"end":412}},{"label":"p","span":{"begin":389,"end":412}},{"label":"table","span":{"begin":413,"end":733}},{"label":"tr","span":{"begin":413,"end":419}},{"label":"th","span":{"begin":413,"end":419}},{"label":"tr","span":{"begin":420,"end":434}},{"label":"th","span":{"begin":420,"end":425}},{"label":"th","span":{"begin":426,"end":429}},{"label":"th","span":{"begin":430,"end":434}},{"label":"tr","span":{"begin":435,"end":499}},{"label":"td","span":{"begin":435,"end":443}},{"label":"td","span":{"begin":443,"end":458}},{"label":"td","span":{"begin":459,"end":477}},{"label":"td","span":{"begin":478,"end":499}},{"label":"tr","span":{"begin":500,"end":540}},{"label":"td","span":{"begin":500,"end":505}},{"label":"td","span":{"begin":505,"end":516}},{"label":"td","span":{"begin":517,"end":528}},{"label":"td","span":{"begin":529,"end":540}},{"label":"tr","span":{"begin":541,"end":602}},{"label":"td","span":{"begin":541,"end":553}},{"label":"td","span":{"begin":553,"end":569}},{"label":"td","span":{"begin":570,"end":586}},{"label":"td","span":{"begin":587,"end":602}},{"label":"tr","span":{"begin":603,"end":655}},{"label":"td","span":{"begin":603,"end":614}},{"label":"td","span":{"begin":614,"end":627}},{"label":"td","span":{"begin":628,"end":641}},{"label":"td","span":{"begin":642,"end":655}},{"label":"tr","span":{"begin":656,"end":694}},{"label":"td","span":{"begin":656,"end":668}},{"label":"td","span":{"begin":669,"end":681}},{"label":"td","span":{"begin":682,"end":694}},{"label":"tr","span":{"begin":695,"end":733}},{"label":"td","span":{"begin":695,"end":707}},{"label":"td","span":{"begin":708,"end":720}},{"label":"td","span":{"begin":721,"end":733}},{"label":"p","span":{"begin":734,"end":989}},{"label":"p","span":{"begin":990,"end":1271}}],"tracks":[{"project":"2_test","denotations":[{"id":"25532820-19827120-11953997","span":{"begin":204,"end":206},"obj":"19827120"},{"id":"25532820-17375988-11953998","span":{"begin":818,"end":820},"obj":"17375988"}],"attributes":[{"subj":"25532820-19827120-11953997","pred":"source","obj":"2_test"},{"subj":"25532820-17375988-11953998","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#e693ec","default":true}]}]}}