PMC:4277126 / 87133-88497 JSONTXT

{"project":"2_test","denotations":[{"id":"25552899-22081616-26094361","span":{"begin":32,"end":35},"obj":"22081616"},{"id":"25552899-22081616-26094362","span":{"begin":674,"end":677},"obj":"22081616"},{"id":"25552899-22081616-26094363","span":{"begin":1123,"end":1126},"obj":"22081616"}],"text":"Clinical study\nAmagase and Nance116 investigated the effect of GoChi consumption on caloric expenditure and changes in morphometric parameters (waist circumference) in healthy adults. Two separate randomized, double-blind, placebo-controlled, small clinical studies were conducted using GoChi and assessing its effects on resting metabolic rate and postprandial energy expenditure as measured by indirect calorimetry after single-bolus intake of three doses of GoChi (30 mL, 60 mL, and 120 mL) and placebo; and waist circumference and other morphometric changes in a 14-day intervention trial (120-mL daily intake) in the subjects (age =34 years, body mass index =29 kg/m2).116 A single bolus of GoChi intake increased postprandial energy expenditure 1–4 hours post-intake over the baseline level in a dose-dependent manner and was significantly higher than the placebo group by 10% at 1 hour post-intake of 120 mL. In a 14-day intervention trial, GoChi was found to significantly decrease waist circumference by 5.5±0.8 cm (n=15) compared with the preintervention measurements and placebo group at postintervention day 15.116 In contrast, the changes in the placebo group (n=14) from preinterventions was 0.9±0.8 cm, which was not statistically significant. These results show that GoChi consumption can increase metabolic rate and reduce the waist circumference."}

{"project":"NEUROSES","denotations":[{"id":"T1991","span":{"begin":150,"end":163},"obj":"PATO_0001648"},{"id":"T1992","span":{"begin":517,"end":530},"obj":"PATO_0001648"},{"id":"T1993","span":{"begin":216,"end":221},"obj":"PATO_0001177"},{"id":"T1994","span":{"begin":243,"end":248},"obj":"PATO_0000587"},{"id":"T1995","span":{"begin":340,"end":344},"obj":"PATO_0001470"},{"id":"T1996","span":{"begin":340,"end":344},"obj":"PATO_0000161"},{"id":"T1997","span":{"begin":362,"end":368},"obj":"PATO_0001021"},{"id":"T1998","span":{"begin":732,"end":738},"obj":"PATO_0001021"},{"id":"T1999","span":{"begin":632,"end":635},"obj":"PATO_0000011"},{"id":"T2000","span":{"begin":632,"end":635},"obj":"CHEBI_84123"},{"id":"T2001","span":{"begin":652,"end":656},"obj":"PATO_0000125"},{"id":"T2002","span":{"begin":709,"end":718},"obj":"PATO_0000470"},{"id":"T2003","span":{"begin":870,"end":875},"obj":"CHEBI_24433"},{"id":"T2004","span":{"begin":1090,"end":1095},"obj":"CHEBI_24433"},{"id":"T2005","span":{"begin":1167,"end":1172},"obj":"CHEBI_24433"},{"id":"T2006","span":{"begin":996,"end":1009},"obj":"PATO_0001648"},{"id":"T2007","span":{"begin":1350,"end":1363},"obj":"PATO_0001648"},{"id":"T2009","span":{"begin":1324,"end":1328},"obj":"PATO_0001470"},{"id":"T2010","span":{"begin":1324,"end":1328},"obj":"PATO_0000161"}],"text":"Clinical study\nAmagase and Nance116 investigated the effect of GoChi consumption on caloric expenditure and changes in morphometric parameters (waist circumference) in healthy adults. Two separate randomized, double-blind, placebo-controlled, small clinical studies were conducted using GoChi and assessing its effects on resting metabolic rate and postprandial energy expenditure as measured by indirect calorimetry after single-bolus intake of three doses of GoChi (30 mL, 60 mL, and 120 mL) and placebo; and waist circumference and other morphometric changes in a 14-day intervention trial (120-mL daily intake) in the subjects (age =34 years, body mass index =29 kg/m2).116 A single bolus of GoChi intake increased postprandial energy expenditure 1–4 hours post-intake over the baseline level in a dose-dependent manner and was significantly higher than the placebo group by 10% at 1 hour post-intake of 120 mL. In a 14-day intervention trial, GoChi was found to significantly decrease waist circumference by 5.5±0.8 cm (n=15) compared with the preintervention measurements and placebo group at postintervention day 15.116 In contrast, the changes in the placebo group (n=14) from preinterventions was 0.9±0.8 cm, which was not statistically significant. These results show that GoChi consumption can increase metabolic rate and reduce the waist circumference."}