PMC:4277126 / 39389-40949 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4277126","sourcedb":"PMC","sourceid":"4277126","source_url":"http://www.ncbi.nlm.nih.gov/pmc/4277126","text":"Prostate cancer\nProstate cancer is the second most common cancer in men worldwide, after lung cancer.50 There were over 903,500 new prostate cancer cases reported worldwide and an estimated 258,400 men died from this disease in 2008.29 In the US, 196,038 men were diagnosed with prostate cancer, and 28,560 men died from this disease in 2010.51 In the UK, 40,975 men were diagnosed with prostate cancer in 2010, and 10,793 men died from this disease in 2011.52 Chemotherapy for prostate cancer usually brings drug resistance and severe adverse reactions in patients. Therefore, new anticancer drugs that can prevent the progression of prostate cancer and execute prostate cancer cells with improved efficacy and reduced side effects are urgently needed.\nThe effects of LBPs on the growth of human prostate cancer cells were examined in vitro and in vivo by Luo et al.53 LBPs inhibited the growth of both PC-3 and DU-145 cells in a dose- and time-dependent manner, by breaking their DNA strands and inducing the apoptosis of these cells. The Bcl-2/Bax expression decreased significantly after LBP treatments and the ratio of Bcl-2/Bax expression following LBP treatment also decreased significantly with a dose–effect relationship,53 which suggested that LBPs regulated the expression of Bcl-2 and Bax to induce apoptosis of PC-3 and DU-145 cells. The animal study showed that LBPs significantly inhibited PC-3 xenograft growth in nude mice with significant reduction of the tumor volume and weight in the LBP-treated group than in those of the control group.53","divisions":[{"label":"Title","span":{"begin":0,"end":15}}],"tracks":[{"project":"2_test","denotations":[{"id":"25552899-23147924-26094238","span":{"begin":101,"end":103},"obj":"23147924"},{"id":"25552899-19735167-26094239","span":{"begin":867,"end":869},"obj":"19735167"},{"id":"25552899-19735167-26094240","span":{"begin":1230,"end":1232},"obj":"19735167"},{"id":"25552899-19735167-26094241","span":{"begin":1558,"end":1560},"obj":"19735167"}],"attributes":[{"subj":"25552899-23147924-26094238","pred":"source","obj":"2_test"},{"subj":"25552899-19735167-26094239","pred":"source","obj":"2_test"},{"subj":"25552899-19735167-26094240","pred":"source","obj":"2_test"},{"subj":"25552899-19735167-26094241","pred":"source","obj":"2_test"}]},{"project":"NEUROSES","denotations":[{"id":"T724","span":{"begin":712,"end":719},"obj":"PATO_0001997"},{"id":"T725","span":{"begin":1062,"end":1071},"obj":"PATO_0001997"},{"id":"T729","span":{"begin":509,"end":513},"obj":"CHEBI_23888"},{"id":"T730","span":{"begin":593,"end":598},"obj":"CHEBI_23888"},{"id":"T731","span":{"begin":514,"end":524},"obj":"PATO_0001046"},{"id":"T732","span":{"begin":941,"end":945},"obj":"PATO_0001309"},{"id":"T733","span":{"begin":941,"end":945},"obj":"PATO_0000165"},{"id":"T734","span":{"begin":982,"end":985},"obj":"CHEBI_16991"},{"id":"T735","span":{"begin":1115,"end":1120},"obj":"PATO_0001038"},{"id":"T736","span":{"begin":1115,"end":1120},"obj":"PATO_0001470"},{"id":"T737","span":{"begin":1174,"end":1183},"obj":"PATO_0001997"},{"id":"T738","span":{"begin":1480,"end":1486},"obj":"PATO_0000918"},{"id":"T739","span":{"begin":1491,"end":1497},"obj":"PATO_0000128"},{"id":"T740","span":{"begin":1517,"end":1522},"obj":"CHEBI_24433"},{"id":"T741","span":{"begin":1552,"end":1557},"obj":"CHEBI_24433"}],"attributes":[{"subj":"T724","pred":"source","obj":"NEUROSES"},{"subj":"T725","pred":"source","obj":"NEUROSES"},{"subj":"T729","pred":"source","obj":"NEUROSES"},{"subj":"T730","pred":"source","obj":"NEUROSES"},{"subj":"T731","pred":"source","obj":"NEUROSES"},{"subj":"T732","pred":"source","obj":"NEUROSES"},{"subj":"T733","pred":"source","obj":"NEUROSES"},{"subj":"T734","pred":"source","obj":"NEUROSES"},{"subj":"T735","pred":"source","obj":"NEUROSES"},{"subj":"T736","pred":"source","obj":"NEUROSES"},{"subj":"T737","pred":"source","obj":"NEUROSES"},{"subj":"T738","pred":"source","obj":"NEUROSES"},{"subj":"T739","pred":"source","obj":"NEUROSES"},{"subj":"T740","pred":"source","obj":"NEUROSES"},{"subj":"T741","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93cbec","default":true},{"id":"NEUROSES","color":"#e5ec93"}]}]}}