PMC:4277126 / 141668-142930 JSONTXT

{"project":"2_test","denotations":[{"id":"25552899-20684332-26094496","span":{"begin":50,"end":53},"obj":"20684332"},{"id":"25552899-21077258-26094497","span":{"begin":273,"end":276},"obj":"21077258"},{"id":"25552899-21077258-26094498","span":{"begin":876,"end":879},"obj":"21077258"}],"text":"Radiation-induced spermatogenic damage\nZhang et al180 explored the protective effects of LBPs on 60Co-γ-induced spermatogenic disturbance in mice and found that LBPs exhibited almost complete recovery from reproductive endocrine disorder and spermatogenic damage. Luo et al181 further confirmed the protective effects of LBPs on radiation-induced spermatogenic damage in male rats exposed to local subchronic 60Co-γ-irradiation. In this study, the effects of LBPs on sperm quantity and motility, sexual ability, serum hormone levels, oxidative status, and testicular tissue DNA damage on days 1, 7, and 14 postdosing were determined. The results showed that LBPs significantly increased the sperm quantity and motility; shortened the erection, capture, and ejaculation latencies; increased the number of captures and ejaculations; and improved the sexual ability of male rats.181 LBPs also played a significant role in the recovery of serum testosterone levels, increased superoxide dismutase activity, decreased MDA levels, promoted oxidative balance, and rescued testicular DNA damage. LBPs have significant protective effects against damage induced by local subchronic exposure to 60Co-γ irradiation, allowing rats to achieve full recovery with LBP treatment."}

{"project":"NEUROSES","denotations":[{"id":"T2951","span":{"begin":518,"end":525},"obj":"CHEBI_24621"},{"id":"T2952","span":{"begin":371,"end":375},"obj":"PATO_0000384"},{"id":"T2953","span":{"begin":866,"end":870},"obj":"PATO_0000384"},{"id":"T2954","span":{"begin":371,"end":375},"obj":"CHEBI_30780"},{"id":"T2955","span":{"begin":866,"end":870},"obj":"CHEBI_30780"},{"id":"T2956","span":{"begin":381,"end":388},"obj":"PATO_0001646"},{"id":"T2957","span":{"begin":381,"end":388},"obj":"PATO_0002425"},{"id":"T2958","span":{"begin":473,"end":481},"obj":"PATO_0000819"},{"id":"T2959","span":{"begin":697,"end":705},"obj":"PATO_0000819"},{"id":"T2960","span":{"begin":574,"end":577},"obj":"CHEBI_16991"},{"id":"T2961","span":{"begin":1076,"end":1079},"obj":"CHEBI_16991"},{"id":"T2962","span":{"begin":677,"end":686},"obj":"PATO_0000470"},{"id":"T2963","span":{"begin":780,"end":789},"obj":"PATO_0000470"},{"id":"T2964","span":{"begin":962,"end":971},"obj":"PATO_0000470"},{"id":"T2965","span":{"begin":720,"end":729},"obj":"PATO_0000574"},{"id":"T2966","span":{"begin":720,"end":729},"obj":"PATO_0002364"},{"id":"T2967","span":{"begin":911,"end":915},"obj":"CHEBI_50906"},{"id":"T2968","span":{"begin":941,"end":953},"obj":"CHEBI_17347"},{"id":"T2969","span":{"begin":972,"end":982},"obj":"CHEBI_18421"},{"id":"T2970","span":{"begin":1003,"end":1012},"obj":"PATO_0001997"},{"id":"T2971","span":{"begin":1013,"end":1016},"obj":"CHEBI_566274"},{"id":"T2972","span":{"begin":1044,"end":1051},"obj":"PATO_0000185"},{"id":"T2973","span":{"begin":1044,"end":1051},"obj":"CHEBI_3612"},{"id":"T2945","span":{"begin":32,"end":38},"obj":"PATO_0001020"},{"id":"T2946","span":{"begin":256,"end":262},"obj":"PATO_0001020"},{"id":"T2947","span":{"begin":361,"end":367},"obj":"PATO_0001020"},{"id":"T2948","span":{"begin":578,"end":584},"obj":"PATO_0001020"},{"id":"T2949","span":{"begin":1137,"end":1143},"obj":"PATO_0001020"},{"id":"T2950","span":{"begin":219,"end":228},"obj":"CHEBI_24621"}],"text":"Radiation-induced spermatogenic damage\nZhang et al180 explored the protective effects of LBPs on 60Co-γ-induced spermatogenic disturbance in mice and found that LBPs exhibited almost complete recovery from reproductive endocrine disorder and spermatogenic damage. Luo et al181 further confirmed the protective effects of LBPs on radiation-induced spermatogenic damage in male rats exposed to local subchronic 60Co-γ-irradiation. In this study, the effects of LBPs on sperm quantity and motility, sexual ability, serum hormone levels, oxidative status, and testicular tissue DNA damage on days 1, 7, and 14 postdosing were determined. The results showed that LBPs significantly increased the sperm quantity and motility; shortened the erection, capture, and ejaculation latencies; increased the number of captures and ejaculations; and improved the sexual ability of male rats.181 LBPs also played a significant role in the recovery of serum testosterone levels, increased superoxide dismutase activity, decreased MDA levels, promoted oxidative balance, and rescued testicular DNA damage. LBPs have significant protective effects against damage induced by local subchronic exposure to 60Co-γ irradiation, allowing rats to achieve full recovery with LBP treatment."}