PMC:4277126 / 139930-141666 JSONTXT

{"project":"2_test","denotations":[{"id":"25552899-16563441-26094490","span":{"begin":54,"end":57},"obj":"16563441"},{"id":"25552899-16563441-26094491","span":{"begin":644,"end":647},"obj":"16563441"},{"id":"25552899-16563441-26094492","span":{"begin":1078,"end":1081},"obj":"16563441"},{"id":"25552899-22295856-26094493","span":{"begin":1189,"end":1192},"obj":"22295856"},{"id":"25552899-22295856-26094494","span":{"begin":1641,"end":1644},"obj":"22295856"},{"id":"25552899-22295856-26094495","span":{"begin":1733,"end":1736},"obj":"22295856"}],"text":"Heat- or H2O2-induced testicular cell damage\nLuo et al178 investigated the effect of LBPs on rat testis damage induced by a physical factor (43°C heat exposure), on DNA damage of mouse testicular cells induced by a chemical factor (H2O2), and on sexual behavior and reproductive function of hemicastrated male rats. The results showed that LBPs provided a protective effect against the testicular tissue damage induced by heat exposure. When compared with negative control, a suitable concentration of LBPs significantly increased testis and epididymis weights, improved SOD activity, and raised sexual hormone levels in the damaged rat testes.178 LBPs exhibited a dose-dependent protective effect against DNA oxidative damage of mouse testicular cells induced by H2O2. LBPs also improved the copulatory performance and reproductive function of hemicastrated male rats, such as shortened penis erection latency and mount latency, regulated secretion of sexual hormones and increased hormone levels, raised accessory sexual organ weights, and improved sperm quantity and quality.178\nLBPs could provide some protective effect against heat stress (HS)-induced apoptosis of germ cells in rats.179 Ninety male Sprague–Dawley rats were randomly divided into five groups of 18 each: control, HS, high-dose LBPs, median-dose LBPs, and low-dose LBPs. The rats of the three LBP groups were given LBPs by intragastric administration. Compared with the HS group, the three LBP groups showed statistically significant decreases in the apoptosis index, the expression level of caspase-3 in germ cells, and the concentration of cytochrome C in the cytosol.179 LBPs protected germ cells against apoptosis via modulation of the mitochondrial pathway.179"}

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