PMC:4277126 / 134692-137038 JSONTXT

{"project":"2_test","denotations":[{"id":"25552899-24275174-26094479","span":{"begin":150,"end":153},"obj":"24275174"},{"id":"25552899-23719879-26094480","span":{"begin":154,"end":157},"obj":"23719879"},{"id":"25552899-15724837-26094481","span":{"begin":372,"end":375},"obj":"15724837"},{"id":"25552899-15724837-26094482","span":{"begin":1052,"end":1055},"obj":"15724837"},{"id":"25552899-15724837-26094483","span":{"begin":1385,"end":1388},"obj":"15724837"},{"id":"25552899-15869449-26094484","span":{"begin":1583,"end":1586},"obj":"15869449"}],"text":"Protective effects against irradiation- or chemotherapy-induced organ toxicities\nBoth irradiation and chemotherapy can induce severe organ toxicities.173,174 LBPs could serve as a very useful adjunct to the cancer therapies such as chemotherapy and radiotherapy. Therapeutic effects of LBPs on mitomycin C-induced myelosuppressive mice were investigated by Hai-Yang et al.175 Mice were intravenously injected with 150 mg/kg mitomycin C for 2 consecutive days to produce severe myelosuppression, and then treated by subcutaneous injection of 100 mg/kg/day or 200 mg/kg/day LBPs for 6 days. Blood samples were collected from the tail veins of mice on days 7, 10, 12, 14, 17, 19, 21, 24, and 27, and peripheral white blood cells, red blood cells, hemoglobin, and platelet counts were monitored. Administration of 100 mg/kg LBPs (LBP-L) on day 14 and 200 mg/kg LBPs (LBP-H) on days 10, 14, 17, 19, and 21 significantly increased peripheral red blood cells, hemoglobin, and hematocrit of myelosuppressive mice compared to mice treated with mitomycin C only.175 LBP-L on days 12 and 14 and LBP-H on days 10, 12, 14, 17, 19, and 21 significantly promoted peripheral platelet recovery of mitomycin C-treated mice compared with the control mice. LBP-H on days 12, 17, 19, and 21 also significantly inhibited the increase of mean platelet volume of myelosuppressive mice compared to the control.175 These results indicate that LBPs significantly enhanced platelet recovery of myelosuppressive mice compared to the control, but did not significantly affect white blood cell recovery.\nGong et al176 investigated the effects of LBPs on irradiation or chemotherapy-induced bone marrow suppression in mice and cultured PBMCs. In the in vivo experiment, mice were irradiated with X-ray or intraperitoneally injected with carboplatin to produce severe myelosuppression. LBPs significantly increased peripheral white blood cell, red blood cell, and platelet counts compared to mice receiving irradiation only. LBPs also significantly increased peripheral white blood cell and red blood cell counts of chemotherapy-induced myelosuppressive mice. This study demonstrates that LBPs promoted the peripheral blood and bone marrow recovery from irradiation or chemotherapy-induced myelosuppression in mice, and the effects may be due to the release of GM-CSF from PBMCs."}