PMC:4195273 / 96931-97727 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"Both gene knockout and overexpression studies of CART have consolidated the stimulatory role of CART in promoting lipid oxidation and inhibiting fat accrual. As discussed above, despite the widely documented anorectic evidence of CART, possibility of an orexigenic role is indisputable. Under certain circumstances, such postulation may provide explanation for the inconsistent or lack of marked phenotypes in terms of energy balance observed in germline CART knockout animals, as well as conditional, developmental stage, or whole brain CART knockout models. Nevertheless, temporal or tissue-specific genetic ablation serves an invaluable means to minimize common pitfalls associated with a germline knockout strategy, such as any secondary effects or compensatory mechanisms during development.","tracks":[]}