PMC:4195273 / 93576-94417 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"The physiological importance of CART is endorsed by the evolutionarily conserved expression patterns in the brain as well as the periphery at regions associated with energy balance, inferring structural hence functional conservation in glucose sensing, lipogenesis regulation and ultimately the control of feeding behavior. The resultant integrated outcome on metabolic modulation also represents the neuronal crosstalk involving similar neuromodulatory peptides between central CART-interfered pathways residing at the hypothalamic and brainstem neurons as well as via the hypothalamic-pituitary-adrenal axis. In comparison with CART in the brain, functional roles of peripheral CART are less established, with indeterminate modes of action speculated to entail either a local independent response, or synergistic effects with central CART.","tracks":[]}