PMC:4195273 / 92990-93575 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"In conclusion, the widely adopted role of CART in the regulation of energy homeostasis has been summarized in this review from the perspectives of genetic and transcriptional associations, anatomical-functional correlation, pharmacological and genetic intervention studies in animal models, as well as implications from sequence variability in human. Nevertheless, the lack of a known CART receptor(s) and specific antagonists, continues to constitute the major challenge in understanding the underlying mechanisms by which CART exerts effects on feeding and neuroendocrine regulation.","tracks":[]}