PMC:4195273 / 8597-10015
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"In addition to the structural conservancy between CART isoforms across species (Douglass et al., 1995; Douglass and Daoud, 1996; Adams et al., 1999; Dey et al., 2003), functional conservation of CART in the mammalian neuroendocrine system has also been implicated in the resembling CART mRNA and peptide distribution pattern in the brain observed between humans, rodents, as well as monkeys (Douglass and Daoud, 1996; Gautvik et al., 1996; Charnay et al., 1999; Cavalcante et al., 2011). As a leptin-regulated neurotransmitter with potent appetite-suppressing activity (Kristensen et al., 1998), CART expression in the CNS is highly localized to distinct brain areas critically involved in the control of energy homeostasis, limbic and sensory functions, as well as throughout the HPA axis (Douglass et al., 1995; Gautvik et al., 1996; Koylu et al., 1997; Charnay et al., 1999; Dominguez, 2006; Hubert and Kuhar, 2008; Cavalcante et al., 2011). Localization analyses of CART expression at the mRNA and peptide levels have demonstrated concordance across studies applying cDNA sequencing (Douglass et al., 1995), in situ hybridization (Douglass et al., 1995; Couceyro et al., 1997) and immunohistochemistry (Koylu et al., 1997). Indeed, CART mRNA has been shown to constitute the third most abundant transcript identified in rat hypothalamus after subtraction of cerebellar and hippocampal mRNAs (Gautvik et al., 1996).","tracks":[{"project":"TEST0","denotations":[{"id":"25352770-97-105-357310","span":{"begin":97,"end":101},"obj":"[\"7891182\"]"},{"id":"25352770-123-131-357311","span":{"begin":123,"end":127},"obj":"[\"8647455\"]"},{"id":"25352770-143-151-357312","span":{"begin":143,"end":147},"obj":"[\"10612705\"]"},{"id":"25352770-161-169-357313","span":{"begin":161,"end":165},"obj":"[\"12584191\"]"},{"id":"25352770-233-241-357314","span":{"begin":412,"end":416},"obj":"[\"8647455\"]"},{"id":"25352770-234-242-357315","span":{"begin":434,"end":438},"obj":"[\"8710940\"]"},{"id":"25352770-224-232-357316","span":{"begin":456,"end":460},"obj":"[\"10609861\"]"},{"id":"25352770-233-241-357317","span":{"begin":481,"end":485},"obj":"[\"22030409\"]"},{"id":"25352770-101-109-357318","span":{"begin":589,"end":593},"obj":"[\"9590691\"]"},{"id":"25352770-227-235-357319","span":{"begin":808,"end":812},"obj":"[\"7891182\"]"},{"id":"25352770-234-242-357320","span":{"begin":830,"end":834},"obj":"[\"8710940\"]"},{"id":"25352770-235-243-357321","span":{"begin":850,"end":854},"obj":"[\"9419833\"]"},{"id":"25352770-229-237-357322","span":{"begin":872,"end":876},"obj":"[\"10609861\"]"},{"id":"25352770-234-242-357323","span":{"begin":889,"end":893},"obj":"[\"16716454\"]"},{"id":"25352770-235-243-357324","span":{"begin":913,"end":917},"obj":"[\"18314190\"]"},{"id":"25352770-233-241-357325","span":{"begin":938,"end":942},"obj":"[\"22030409\"]"},{"id":"25352770-160-168-357326","span":{"begin":1105,"end":1109},"obj":"[\"7891182\"]"},{"id":"25352770-207-215-357327","span":{"begin":1152,"end":1156},"obj":"[\"7891182\"]"},{"id":"25352770-230-238-357328","span":{"begin":1175,"end":1179},"obj":"[\"9243343\"]"},{"id":"25352770-235-243-357329","span":{"begin":1221,"end":1225},"obj":"[\"9419833\"]"},{"id":"25352770-184-192-357330","span":{"begin":1412,"end":1416},"obj":"[\"8710940\"]"}],"attributes":[{"subj":"25352770-97-105-357310","pred":"source","obj":"TEST0"},{"subj":"25352770-123-131-357311","pred":"source","obj":"TEST0"},{"subj":"25352770-143-151-357312","pred":"source","obj":"TEST0"},{"subj":"25352770-161-169-357313","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357314","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357315","pred":"source","obj":"TEST0"},{"subj":"25352770-224-232-357316","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357317","pred":"source","obj":"TEST0"},{"subj":"25352770-101-109-357318","pred":"source","obj":"TEST0"},{"subj":"25352770-227-235-357319","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357320","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357321","pred":"source","obj":"TEST0"},{"subj":"25352770-229-237-357322","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357323","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357324","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357325","pred":"source","obj":"TEST0"},{"subj":"25352770-160-168-357326","pred":"source","obj":"TEST0"},{"subj":"25352770-207-215-357327","pred":"source","obj":"TEST0"},{"subj":"25352770-230-238-357328","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357329","pred":"source","obj":"TEST0"},{"subj":"25352770-184-192-357330","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"25352770-7891182-357310","span":{"begin":97,"end":101},"obj":"7891182"},{"id":"25352770-8647455-357311","span":{"begin":123,"end":127},"obj":"8647455"},{"id":"25352770-10612705-357312","span":{"begin":143,"end":147},"obj":"10612705"},{"id":"25352770-12584191-357313","span":{"begin":161,"end":165},"obj":"12584191"},{"id":"25352770-8647455-357314","span":{"begin":412,"end":416},"obj":"8647455"},{"id":"25352770-8710940-357315","span":{"begin":434,"end":438},"obj":"8710940"},{"id":"25352770-10609861-357316","span":{"begin":456,"end":460},"obj":"10609861"},{"id":"25352770-22030409-357317","span":{"begin":481,"end":485},"obj":"22030409"},{"id":"25352770-9590691-357318","span":{"begin":589,"end":593},"obj":"9590691"},{"id":"25352770-7891182-357319","span":{"begin":808,"end":812},"obj":"7891182"},{"id":"25352770-8710940-357320","span":{"begin":830,"end":834},"obj":"8710940"},{"id":"25352770-9419833-357321","span":{"begin":850,"end":854},"obj":"9419833"},{"id":"25352770-10609861-357322","span":{"begin":872,"end":876},"obj":"10609861"},{"id":"25352770-16716454-357323","span":{"begin":889,"end":893},"obj":"16716454"},{"id":"25352770-18314190-357324","span":{"begin":913,"end":917},"obj":"18314190"},{"id":"25352770-22030409-357325","span":{"begin":938,"end":942},"obj":"22030409"},{"id":"25352770-7891182-357326","span":{"begin":1105,"end":1109},"obj":"7891182"},{"id":"25352770-7891182-357327","span":{"begin":1152,"end":1156},"obj":"7891182"},{"id":"25352770-9243343-357328","span":{"begin":1175,"end":1179},"obj":"9243343"},{"id":"25352770-9419833-357329","span":{"begin":1221,"end":1225},"obj":"9419833"},{"id":"25352770-8710940-357330","span":{"begin":1412,"end":1416},"obj":"8710940"}],"at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