PMC:4195273 / 75170-76725 JSONTXT

{"project":"TEST0","denotations":[{"id":"25352770-162-170-357850","span":{"begin":477,"end":481},"obj":"[\"11564703\"]"},{"id":"25352770-184-192-357851","span":{"begin":499,"end":503},"obj":"[\"16762458\"]"},{"id":"25352770-210-218-357852","span":{"begin":1200,"end":1204},"obj":"[\"11850744\"]"},{"id":"25352770-231-239-357853","span":{"begin":1221,"end":1225},"obj":"[\"17182122\"]"},{"id":"25352770-232-240-357854","span":{"begin":1506,"end":1510},"obj":"[\"11850744\"]"},{"id":"25352770-228-236-357855","span":{"begin":1528,"end":1532},"obj":"[\"14700744\"]"},{"id":"25352770-219-227-357856","span":{"begin":1549,"end":1553},"obj":"[\"17182122\"]"}],"text":"In spite of a lack of direct indication endorsing a function of CART in modulating energy expenditure, comparing the respiratory exchange ratio (RER) between CART knockout animals and WT counterparts may shed light on any potential effects of CART ablation on energy metabolism through the fuel source preferences. Although no measurable difference was described in knockout animals in the respiratory quotient derived from RER as reported by previous studies (Asnicar et al., 2001; Moffett et al., 2006), a notably lower RER has been detected in our new CART knockout mice. Consistency in the lower RER particularly during the dark photoperiod was shown across both nutritional statuses, signifying that fat was preferentially metabolized over carbohydrates to supply energy for the body. A possible explanation for this could be the higher fat content in knockout animals, which may lead to the predominant fuel source based on the relative higher availability of fat than carbohydrates. On the other hand, a suppressed average respiratory quotient was demonstrated in both normal and DIO rats chronically overexpressing central CART compared to vehicle-treated controls (Rohner-Jeanrenaud et al., 2002; Qing and Chen, 2007). The reduction was exaggerated during the dark phase, under both regular feeding and fasting-refeeding conditions, indicating a stimulatory role of CART in promoting lipid oxidation and limiting fat storage, hence inhibiting excessive body fat accrual (Rohner-Jeanrenaud et al., 2002; Wortley et al., 2004; Qing and Chen, 2007)."}

{"project":"0_colil","denotations":[{"id":"25352770-11564703-357850","span":{"begin":477,"end":481},"obj":"11564703"},{"id":"25352770-16762458-357851","span":{"begin":499,"end":503},"obj":"16762458"},{"id":"25352770-11850744-357852","span":{"begin":1200,"end":1204},"obj":"11850744"},{"id":"25352770-17182122-357853","span":{"begin":1221,"end":1225},"obj":"17182122"},{"id":"25352770-11850744-357854","span":{"begin":1506,"end":1510},"obj":"11850744"},{"id":"25352770-14700744-357855","span":{"begin":1528,"end":1532},"obj":"14700744"},{"id":"25352770-17182122-357856","span":{"begin":1549,"end":1553},"obj":"17182122"}],"text":"In spite of a lack of direct indication endorsing a function of CART in modulating energy expenditure, comparing the respiratory exchange ratio (RER) between CART knockout animals and WT counterparts may shed light on any potential effects of CART ablation on energy metabolism through the fuel source preferences. Although no measurable difference was described in knockout animals in the respiratory quotient derived from RER as reported by previous studies (Asnicar et al., 2001; Moffett et al., 2006), a notably lower RER has been detected in our new CART knockout mice. Consistency in the lower RER particularly during the dark photoperiod was shown across both nutritional statuses, signifying that fat was preferentially metabolized over carbohydrates to supply energy for the body. A possible explanation for this could be the higher fat content in knockout animals, which may lead to the predominant fuel source based on the relative higher availability of fat than carbohydrates. On the other hand, a suppressed average respiratory quotient was demonstrated in both normal and DIO rats chronically overexpressing central CART compared to vehicle-treated controls (Rohner-Jeanrenaud et al., 2002; Qing and Chen, 2007). The reduction was exaggerated during the dark phase, under both regular feeding and fasting-refeeding conditions, indicating a stimulatory role of CART in promoting lipid oxidation and limiting fat storage, hence inhibiting excessive body fat accrual (Rohner-Jeanrenaud et al., 2002; Wortley et al., 2004; Qing and Chen, 2007)."}

{"project":"2_test","denotations":[{"id":"25352770-11564703-38284839","span":{"begin":477,"end":481},"obj":"11564703"},{"id":"25352770-16762458-38284840","span":{"begin":499,"end":503},"obj":"16762458"},{"id":"25352770-11850744-38284841","span":{"begin":1200,"end":1204},"obj":"11850744"},{"id":"25352770-17182122-38284842","span":{"begin":1221,"end":1225},"obj":"17182122"},{"id":"25352770-11850744-38284843","span":{"begin":1506,"end":1510},"obj":"11850744"},{"id":"25352770-14700744-38284844","span":{"begin":1528,"end":1532},"obj":"14700744"},{"id":"25352770-17182122-38284845","span":{"begin":1549,"end":1553},"obj":"17182122"}],"text":"In spite of a lack of direct indication endorsing a function of CART in modulating energy expenditure, comparing the respiratory exchange ratio (RER) between CART knockout animals and WT counterparts may shed light on any potential effects of CART ablation on energy metabolism through the fuel source preferences. Although no measurable difference was described in knockout animals in the respiratory quotient derived from RER as reported by previous studies (Asnicar et al., 2001; Moffett et al., 2006), a notably lower RER has been detected in our new CART knockout mice. Consistency in the lower RER particularly during the dark photoperiod was shown across both nutritional statuses, signifying that fat was preferentially metabolized over carbohydrates to supply energy for the body. A possible explanation for this could be the higher fat content in knockout animals, which may lead to the predominant fuel source based on the relative higher availability of fat than carbohydrates. On the other hand, a suppressed average respiratory quotient was demonstrated in both normal and DIO rats chronically overexpressing central CART compared to vehicle-treated controls (Rohner-Jeanrenaud et al., 2002; Qing and Chen, 2007). The reduction was exaggerated during the dark phase, under both regular feeding and fasting-refeeding conditions, indicating a stimulatory role of CART in promoting lipid oxidation and limiting fat storage, hence inhibiting excessive body fat accrual (Rohner-Jeanrenaud et al., 2002; Wortley et al., 2004; Qing and Chen, 2007)."}