PMC:4195273 / 72901-73600 JSONTXT

{"project":"TEST0","denotations":[{"id":"25352770-205-213-357832","span":{"begin":619,"end":623},"obj":"[\"11156435\"]"},{"id":"25352770-226-234-357833","span":{"begin":640,"end":644},"obj":"[\"17182122\"]"},{"id":"25352770-230-238-357834","span":{"begin":693,"end":697},"obj":"[\"17182122\"]"}],"text":"In addition to fat mass, lean mass constitutes another major determinant of energy homeostasis that directly influences energy expenditure. As opposed to the increase in fat mass, whole body lean mass of our CART-deficient mice was distinctly lower compared to WT controls regardless of dietary treatments. Similarly, the reduction was consistent across both periods of DXA measurements at 10 and 14 weeks of age. Intriguingly, research investigating the effects of chronic central CART infusion in genetically normal DIO rats reported a diminished body weight gain primarily due to a loss of lean mass (Larsen et al., 2000; Qing and Chen, 2007), while fat mass was unaffected (Qing and Chen, 2007)."}

{"project":"0_colil","denotations":[{"id":"25352770-11156435-357832","span":{"begin":619,"end":623},"obj":"11156435"},{"id":"25352770-17182122-357833","span":{"begin":640,"end":644},"obj":"17182122"},{"id":"25352770-17182122-357834","span":{"begin":693,"end":697},"obj":"17182122"}],"text":"In addition to fat mass, lean mass constitutes another major determinant of energy homeostasis that directly influences energy expenditure. As opposed to the increase in fat mass, whole body lean mass of our CART-deficient mice was distinctly lower compared to WT controls regardless of dietary treatments. Similarly, the reduction was consistent across both periods of DXA measurements at 10 and 14 weeks of age. Intriguingly, research investigating the effects of chronic central CART infusion in genetically normal DIO rats reported a diminished body weight gain primarily due to a loss of lean mass (Larsen et al., 2000; Qing and Chen, 2007), while fat mass was unaffected (Qing and Chen, 2007)."}

{"project":"2_test","denotations":[{"id":"25352770-11156435-38284821","span":{"begin":619,"end":623},"obj":"11156435"},{"id":"25352770-17182122-38284822","span":{"begin":640,"end":644},"obj":"17182122"},{"id":"25352770-17182122-38284823","span":{"begin":693,"end":697},"obj":"17182122"}],"text":"In addition to fat mass, lean mass constitutes another major determinant of energy homeostasis that directly influences energy expenditure. As opposed to the increase in fat mass, whole body lean mass of our CART-deficient mice was distinctly lower compared to WT controls regardless of dietary treatments. Similarly, the reduction was consistent across both periods of DXA measurements at 10 and 14 weeks of age. Intriguingly, research investigating the effects of chronic central CART infusion in genetically normal DIO rats reported a diminished body weight gain primarily due to a loss of lean mass (Larsen et al., 2000; Qing and Chen, 2007), while fat mass was unaffected (Qing and Chen, 2007)."}