PMC:4195273 / 72004-72900
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"Amongst a multitude of potential factors contributing to the enhanced body weight in CART KO models, the gain in fat mass has been considered the most important (Asnicar et al., 2001). This is concordant with results from our novel CART KO model, where body composition analysis by dual-energy X-ray absorptiometry (DXA) revealed a pronounced increase in adiposity independent of diet. The gain in whole body fat mass was further confirmed by tissue dissection showing significantly elevated fat masses in all white adipose tissues, including the inguinal, epididymal, mesenteric and retroperitoneal regions. This also suggests an important function of CART in lipid metabolism, where CART has been linked to inhibition of lipogenesis and stimulation of lipid substrate mobilization and utilization (Rohner-Jeanrenaud et al., 2002; Wortley et al., 2004; Vasseur et al., 2007; Banke et al., 2013).","tracks":[{"project":"TEST0","denotations":[{"id":"25352770-178-186-357827","span":{"begin":178,"end":182},"obj":"[\"11564703\"]"},{"id":"25352770-217-225-357828","span":{"begin":826,"end":830},"obj":"[\"11850744\"]"},{"id":"25352770-234-242-357829","span":{"begin":848,"end":852},"obj":"[\"14700744\"]"},{"id":"25352770-229-237-357830","span":{"begin":870,"end":874},"obj":"[\"17008116\"]"},{"id":"25352770-232-240-357831","span":{"begin":890,"end":894},"obj":"[\"23318496\"]"}],"attributes":[{"subj":"25352770-178-186-357827","pred":"source","obj":"TEST0"},{"subj":"25352770-217-225-357828","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357829","pred":"source","obj":"TEST0"},{"subj":"25352770-229-237-357830","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357831","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"25352770-11564703-357827","span":{"begin":178,"end":182},"obj":"11564703"},{"id":"25352770-11850744-357828","span":{"begin":826,"end":830},"obj":"11850744"},{"id":"25352770-14700744-357829","span":{"begin":848,"end":852},"obj":"14700744"},{"id":"25352770-17008116-357830","span":{"begin":870,"end":874},"obj":"17008116"},{"id":"25352770-23318496-357831","span":{"begin":890,"end":894},"obj":"23318496"}],"attributes":[{"subj":"25352770-11564703-357827","pred":"source","obj":"0_colil"},{"subj":"25352770-11850744-357828","pred":"source","obj":"0_colil"},{"subj":"25352770-14700744-357829","pred":"source","obj":"0_colil"},{"subj":"25352770-17008116-357830","pred":"source","obj":"0_colil"},{"subj":"25352770-23318496-357831","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"25352770-11564703-38284816","span":{"begin":178,"end":182},"obj":"11564703"},{"id":"25352770-11850744-38284817","span":{"begin":826,"end":830},"obj":"11850744"},{"id":"25352770-14700744-38284818","span":{"begin":848,"end":852},"obj":"14700744"},{"id":"25352770-17008116-38284819","span":{"begin":870,"end":874},"obj":"17008116"},{"id":"25352770-23318496-38284820","span":{"begin":890,"end":894},"obj":"23318496"}],"attributes":[{"subj":"25352770-11564703-38284816","pred":"source","obj":"2_test"},{"subj":"25352770-11850744-38284817","pred":"source","obj":"2_test"},{"subj":"25352770-14700744-38284818","pred":"source","obj":"2_test"},{"subj":"25352770-17008116-38284819","pred":"source","obj":"2_test"},{"subj":"25352770-23318496-38284820","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#eca693","default":true},{"id":"0_colil","color":"#9399ec"},{"id":"2_test","color":"#b3ec93"}]}]}}