PMC:4195273 / 70233-72003
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"Interestingly, fasting-induced food intake experiments in our novel CART KO model suggest that lack of CART may be beneficial for body weight conservation during starvation. In our study, chow-fed CART KO animals showed a slightly lower food consumption compared with WT during a refeeding period following a 24-h fast, yet demonstrated a similar degree and pace of recovery in body weight, implying that less food might be required for returning to the pre-fast weight. On the other hand, the same CART KO mice on HFD experienced a less dramatic drop in body weight upon fasting, and accordingly showed a more effective weight regain to baseline during refeeding. Such improved reactions to food deprivation may be correlated to the observed difference in growth and possibly attributable to events in the interaction between CART and an improved stress response in CART KO mice, consistent with a role of the CART system in stress and anxiety-like responses (Koylu et al., 2000; Stanley et al., 2001, 2004; Kong et al., 2003; Larsen et al., 2003; Vrang et al., 2003; Dominguez et al., 2004a; Smith et al., 2004; Gozen et al., 2007; Hunter et al., 2007; Rogge et al., 2008; Nakhate et al., 2011). For example, i.c.v. CART has been reported to substantially influence the plasma levels of various stress hormones, such as adrenocorticotropic hormone and corticosterone (Stanley et al., 2001). Furthermore, anatomical implication has also been provided by the expression of CART transcript and peptide at various levels of the HPA axis as well as other stress-related areas in the CNS (Douglass et al., 1995; Couceyro et al., 1997; Koylu et al., 1997, 1998; Elias et al., 1998; Broberger, 1999; Larsen et al., 2003; Vrang, 2006; Rogge et al., 2008; Nakhate et al., 2011).","tracks":[{"project":"TEST0","denotations":[{"id":"25352770-232-240-357804","span":{"begin":975,"end":979},"obj":"[\"10854588\"]"},{"id":"25352770-233-241-357805","span":{"begin":997,"end":1001},"obj":"[\"11223006\"]"},{"id":"25352770-235-243-357806","span":{"begin":1003,"end":1007},"obj":"[\"15138156\"]"},{"id":"25352770-232-240-357807","span":{"begin":1022,"end":1026},"obj":"[\"12958177\"]"},{"id":"25352770-224-232-357808","span":{"begin":1043,"end":1047},"obj":"[\"12588509\"]"},{"id":"25352770-231-239-357809","span":{"begin":1063,"end":1067},"obj":"[\"12591118\"]"},{"id":"25352770-233-241-357811","span":{"begin":1108,"end":1112},"obj":"[\"15271883\"]"},{"id":"25352770-231-239-357812","span":{"begin":1128,"end":1132},"obj":"[\"17447258\"]"},{"id":"25352770-233-241-357813","span":{"begin":1149,"end":1153},"obj":"[\"17434149\"]"},{"id":"25352770-232-240-357814","span":{"begin":1169,"end":1173},"obj":"[\"18802445\"]"},{"id":"25352770-231-239-357815","span":{"begin":1191,"end":1195},"obj":"[\"21060312\"]"},{"id":"25352770-168-176-357816","span":{"begin":1386,"end":1390},"obj":"[\"11223006\"]"},{"id":"25352770-209-217-357817","span":{"begin":1602,"end":1606},"obj":"[\"7891182\"]"},{"id":"25352770-232-240-357818","span":{"begin":1625,"end":1629},"obj":"[\"9243343\"]"},{"id":"25352770-228-236-357819","span":{"begin":1645,"end":1649},"obj":"[\"9419833\"]"},{"id":"25352770-234-242-357820","span":{"begin":1651,"end":1655},"obj":"[\"9527537\"]"},{"id":"25352770-233-241-357821","span":{"begin":1671,"end":1675},"obj":"[\"9883730\"]"},{"id":"25352770-233-241-357822","span":{"begin":1688,"end":1692},"obj":"[\"10612702\"]"},{"id":"25352770-231-239-357823","span":{"begin":1709,"end":1713},"obj":"[\"12588509\"]"},{"id":"25352770-233-241-357824","span":{"begin":1722,"end":1726},"obj":"[\"16765484\"]"},{"id":"25352770-230-238-357825","span":{"begin":1742,"end":1746},"obj":"[\"18802445\"]"},{"id":"25352770-234-242-357826","span":{"begin":1764,"end":1768},"obj":"[\"21060312\"]"}],"attributes":[{"subj":"25352770-232-240-357804","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357805","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357806","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357807","pred":"source","obj":"TEST0"},{"subj":"25352770-224-232-357808","pred":"source","obj":"TEST0"},{"subj":"25352770-231-239-357809","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357811","pred":"source","obj":"TEST0"},{"subj":"25352770-231-239-357812","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357813","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357814","pred":"source","obj":"TEST0"},{"subj":"25352770-231-239-357815","pred":"source","obj":"TEST0"},{"subj":"25352770-168-176-357816","pred":"source","obj":"TEST0"},{"subj":"25352770-209-217-357817","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357818","pred":"source","obj":"TEST0"},{"subj":"25352770-228-236-357819","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357820","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357821","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357822","pred":"source","obj":"TEST0"},{"subj":"25352770-231-239-357823","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357824","pred":"source","obj":"TEST0"},{"subj":"25352770-230-238-357825","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357826","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"25352770-10854588-357804","span":{"begin":975,"end":979},"obj":"10854588"},{"id":"25352770-11223006-357805","span":{"begin":997,"end":1001},"obj":"11223006"},{"id":"25352770-15138156-357806","span":{"begin":1003,"end":1007},"obj":"15138156"},{"id":"25352770-12958177-357807","span":{"begin":1022,"end":1026},"obj":"12958177"},{"id":"25352770-12588509-357808","span":{"begin":1043,"end":1047},"obj":"12588509"},{"id":"25352770-12591118-357809","span":{"begin":1063,"end":1067},"obj":"12591118"},{"id":"25352770-15271883-357811","span":{"begin":1108,"end":1112},"obj":"15271883"},{"id":"25352770-17447258-357812","span":{"begin":1128,"end":1132},"obj":"17447258"},{"id":"25352770-17434149-357813","span":{"begin":1149,"end":1153},"obj":"17434149"},{"id":"25352770-18802445-357814","span":{"begin":1169,"end":1173},"obj":"18802445"},{"id":"25352770-21060312-357815","span":{"begin":1191,"end":1195},"obj":"21060312"},{"id":"25352770-11223006-357816","span":{"begin":1386,"end":1390},"obj":"11223006"},{"id":"25352770-7891182-357817","span":{"begin":1602,"end":1606},"obj":"7891182"},{"id":"25352770-9243343-357818","span":{"begin":1625,"end":1629},"obj":"9243343"},{"id":"25352770-9419833-357819","span":{"begin":1645,"end":1649},"obj":"9419833"},{"id":"25352770-9527537-357820","span":{"begin":1651,"end":1655},"obj":"9527537"},{"id":"25352770-9883730-357821","span":{"begin":1671,"end":1675},"obj":"9883730"},{"id":"25352770-10612702-357822","span":{"begin":1688,"end":1692},"obj":"10612702"},{"id":"25352770-12588509-357823","span":{"begin":1709,"end":1713},"obj":"12588509"},{"id":"25352770-16765484-357824","span":{"begin":1722,"end":1726},"obj":"16765484"},{"id":"25352770-18802445-357825","span":{"begin":1742,"end":1746},"obj":"18802445"},{"id":"25352770-21060312-357826","span":{"begin":1764,"end":1768},"obj":"21060312"}],"attributes":[{"subj":"25352770-10854588-357804","pred":"source","obj":"0_colil"},{"subj":"25352770-11223006-357805","pred":"source","obj":"0_colil"},{"subj":"25352770-15138156-357806","pred":"source","obj":"0_colil"},{"subj":"25352770-12958177-357807","pred":"source","obj":"0_colil"},{"subj":"25352770-12588509-357808","pred":"source","obj":"0_colil"},{"subj":"25352770-12591118-357809","pred":"source","obj":"0_colil"},{"subj":"25352770-15271883-357811","pred":"source","obj":"0_colil"},{"subj":"25352770-17447258-357812","pred":"source","obj":"0_colil"},{"subj":"25352770-17434149-357813","pred":"source","obj":"0_colil"},{"subj":"25352770-18802445-357814","pred":"source","obj":"0_colil"},{"subj":"25352770-21060312-357815","pred":"source","obj":"0_colil"},{"subj":"25352770-11223006-357816","pred":"source","obj":"0_colil"},{"subj":"25352770-7891182-357817","pred":"source","obj":"0_colil"},{"subj":"25352770-9243343-357818","pred":"source","obj":"0_colil"},{"subj":"25352770-9419833-357819","pred":"source","obj":"0_colil"},{"subj":"25352770-9527537-357820","pred":"source","obj":"0_colil"},{"subj":"25352770-9883730-357821","pred":"source","obj":"0_colil"},{"subj":"25352770-10612702-357822","pred":"source","obj":"0_colil"},{"subj":"25352770-12588509-357823","pred":"source","obj":"0_colil"},{"subj":"25352770-16765484-357824","pred":"source","obj":"0_colil"},{"subj":"25352770-18802445-357825","pred":"source","obj":"0_colil"},{"subj":"25352770-21060312-357826","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"25352770-10854588-38284793","span":{"begin":975,"end":979},"obj":"10854588"},{"id":"25352770-11223006-38284794","span":{"begin":997,"end":1001},"obj":"11223006"},{"id":"25352770-15138156-38284795","span":{"begin":1003,"end":1007},"obj":"15138156"},{"id":"25352770-12958177-38284796","span":{"begin":1022,"end":1026},"obj":"12958177"},{"id":"25352770-12588509-38284797","span":{"begin":1043,"end":1047},"obj":"12588509"},{"id":"25352770-12591118-38284798","span":{"begin":1063,"end":1067},"obj":"12591118"},{"id":"25352770-15271883-38284800","span":{"begin":1108,"end":1112},"obj":"15271883"},{"id":"25352770-17447258-38284801","span":{"begin":1128,"end":1132},"obj":"17447258"},{"id":"25352770-17434149-38284802","span":{"begin":1149,"end":1153},"obj":"17434149"},{"id":"25352770-18802445-38284803","span":{"begin":1169,"end":1173},"obj":"18802445"},{"id":"25352770-21060312-38284804","span":{"begin":1191,"end":1195},"obj":"21060312"},{"id":"25352770-11223006-38284805","span":{"begin":1386,"end":1390},"obj":"11223006"},{"id":"25352770-7891182-38284806","span":{"begin":1602,"end":1606},"obj":"7891182"},{"id":"25352770-9243343-38284807","span":{"begin":1625,"end":1629},"obj":"9243343"},{"id":"25352770-9419833-38284808","span":{"begin":1645,"end":1649},"obj":"9419833"},{"id":"25352770-9527537-38284809","span":{"begin":1651,"end":1655},"obj":"9527537"},{"id":"25352770-9883730-38284810","span":{"begin":1671,"end":1675},"obj":"9883730"},{"id":"25352770-10612702-38284811","span":{"begin":1688,"end":1692},"obj":"10612702"},{"id":"25352770-12588509-38284812","span":{"begin":1709,"end":1713},"obj":"12588509"},{"id":"25352770-16765484-38284813","span":{"begin":1722,"end":1726},"obj":"16765484"},{"id":"25352770-18802445-38284814","span":{"begin":1742,"end":1746},"obj":"18802445"},{"id":"25352770-21060312-38284815","span":{"begin":1764,"end":1768},"obj":"21060312"}],"attributes":[{"subj":"25352770-10854588-38284793","pred":"source","obj":"2_test"},{"subj":"25352770-11223006-38284794","pred":"source","obj":"2_test"},{"subj":"25352770-15138156-38284795","pred":"source","obj":"2_test"},{"subj":"25352770-12958177-38284796","pred":"source","obj":"2_test"},{"subj":"25352770-12588509-38284797","pred":"source","obj":"2_test"},{"subj":"25352770-12591118-38284798","pred":"source","obj":"2_test"},{"subj":"25352770-15271883-38284800","pred":"source","obj":"2_test"},{"subj":"25352770-17447258-38284801","pred":"source","obj":"2_test"},{"subj":"25352770-17434149-38284802","pred":"source","obj":"2_test"},{"subj":"25352770-18802445-38284803","pred":"source","obj":"2_test"},{"subj":"25352770-21060312-38284804","pred":"source","obj":"2_test"},{"subj":"25352770-11223006-38284805","pred":"source","obj":"2_test"},{"subj":"25352770-7891182-38284806","pred":"source","obj":"2_test"},{"subj":"25352770-9243343-38284807","pred":"source","obj":"2_test"},{"subj":"25352770-9419833-38284808","pred":"source","obj":"2_test"},{"subj":"25352770-9527537-38284809","pred":"source","obj":"2_test"},{"subj":"25352770-9883730-38284810","pred":"source","obj":"2_test"},{"subj":"25352770-10612702-38284811","pred":"source","obj":"2_test"},{"subj":"25352770-12588509-38284812","pred":"source","obj":"2_test"},{"subj":"25352770-16765484-38284813","pred":"source","obj":"2_test"},{"subj":"25352770-18802445-38284814","pred":"source","obj":"2_test"},{"subj":"25352770-21060312-38284815","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93eccc","default":true},{"id":"0_colil","color":"#ecb293"},{"id":"2_test","color":"#9893ec"}]}]}}