PMC:4195273 / 66755-67686 JSONTXT

{"project":"TEST0","denotations":[{"id":"25352770-183-191-357785","span":{"begin":183,"end":187},"obj":"[\"11564703\"]"},{"id":"25352770-206-214-357786","span":{"begin":206,"end":210},"obj":"[\"16099925\"]"},{"id":"25352770-231-239-357787","span":{"begin":231,"end":235},"obj":"[\"15724149\"]"},{"id":"25352770-233-241-357788","span":{"begin":258,"end":262},"obj":"[\"16131814\"]"},{"id":"25352770-226-234-357789","span":{"begin":279,"end":283},"obj":"[\"15927717\"]"},{"id":"25352770-235-243-357790","span":{"begin":301,"end":305},"obj":"[\"16762458\"]"},{"id":"25352770-231-239-357791","span":{"begin":323,"end":327},"obj":"[\"16621045\"]"}],"text":"In order to gain further insight into the functional consequences of reduced or absent CART expression, several knockout models have been generated and characterized (Asnicar et al., 2001; Couceyro et al., 2005; Elefteriou et al., 2005; Osei-Hyiaman et al., 2005; Wierup et al., 2005; Moffett et al., 2006; Steiner et al., 2006) (Table 2). The phenotypic effects resulting from CART gene targeting approaches have in part shown inconsistency between studies, however, displayed a general trend in promoting positive energy balance. This in overall terms is also similar with results obtained from our novel CART knockout (KO) model, which was generated from a conditional version that was crossed with an oozyte-specific Cre line. Collective evidence regarding the role of CART in energy homeostasis from a few representative studies conducted by independent research groups (Table 2) as well as in-house results will be discussed."}

{"project":"0_colil","denotations":[{"id":"25352770-11564703-357785","span":{"begin":183,"end":187},"obj":"11564703"},{"id":"25352770-16099925-357786","span":{"begin":206,"end":210},"obj":"16099925"},{"id":"25352770-15724149-357787","span":{"begin":231,"end":235},"obj":"15724149"},{"id":"25352770-16131814-357788","span":{"begin":258,"end":262},"obj":"16131814"},{"id":"25352770-15927717-357789","span":{"begin":279,"end":283},"obj":"15927717"},{"id":"25352770-16762458-357790","span":{"begin":301,"end":305},"obj":"16762458"},{"id":"25352770-16621045-357791","span":{"begin":323,"end":327},"obj":"16621045"}],"text":"In order to gain further insight into the functional consequences of reduced or absent CART expression, several knockout models have been generated and characterized (Asnicar et al., 2001; Couceyro et al., 2005; Elefteriou et al., 2005; Osei-Hyiaman et al., 2005; Wierup et al., 2005; Moffett et al., 2006; Steiner et al., 2006) (Table 2). The phenotypic effects resulting from CART gene targeting approaches have in part shown inconsistency between studies, however, displayed a general trend in promoting positive energy balance. This in overall terms is also similar with results obtained from our novel CART knockout (KO) model, which was generated from a conditional version that was crossed with an oozyte-specific Cre line. Collective evidence regarding the role of CART in energy homeostasis from a few representative studies conducted by independent research groups (Table 2) as well as in-house results will be discussed."}

{"project":"2_test","denotations":[{"id":"25352770-11564703-38284774","span":{"begin":183,"end":187},"obj":"11564703"},{"id":"25352770-16099925-38284775","span":{"begin":206,"end":210},"obj":"16099925"},{"id":"25352770-15724149-38284776","span":{"begin":231,"end":235},"obj":"15724149"},{"id":"25352770-16131814-38284777","span":{"begin":258,"end":262},"obj":"16131814"},{"id":"25352770-15927717-38284778","span":{"begin":279,"end":283},"obj":"15927717"},{"id":"25352770-16762458-38284779","span":{"begin":301,"end":305},"obj":"16762458"},{"id":"25352770-16621045-38284780","span":{"begin":323,"end":327},"obj":"16621045"}],"text":"In order to gain further insight into the functional consequences of reduced or absent CART expression, several knockout models have been generated and characterized (Asnicar et al., 2001; Couceyro et al., 2005; Elefteriou et al., 2005; Osei-Hyiaman et al., 2005; Wierup et al., 2005; Moffett et al., 2006; Steiner et al., 2006) (Table 2). The phenotypic effects resulting from CART gene targeting approaches have in part shown inconsistency between studies, however, displayed a general trend in promoting positive energy balance. This in overall terms is also similar with results obtained from our novel CART knockout (KO) model, which was generated from a conditional version that was crossed with an oozyte-specific Cre line. Collective evidence regarding the role of CART in energy homeostasis from a few representative studies conducted by independent research groups (Table 2) as well as in-house results will be discussed."}