PMC:4195273 / 61304-62940
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"Despite the body of evidence endorsing the plausibility of the Acb as a site for CART-directed anorexia, the appetite-regulating effects produced by intra-accumbal CART likely represent part of the reward and motivational responses derived from an interaction between CART and the dopaminergic system in the Acb. Multiple lines of evidence have suggested an inhibitory role of endogenous accumbal CART in addiction-relevant behaviors, which are speculated to act in concert with feeding modulation as well as the locomotive effects mediated by the dopaminergic circuits (Kim et al., 2003; Jaworski et al., 2008; Hubert et al., 2010; Job and Kuhar, 2012; Upadhya et al., 2012). For instance, substantial innervations have been described for CART-containing neurons in the ventral pallidum, a key nucleus harboring accumbal efferents, where CART-IR terminals were reported to compose symmetric synapses resembling inhibitory GABAergic synapses (Hubert et al., 2010). Whilst intra-accumbal administration of CART alone produced no effect on locomotor activity, co-injection with cocaine or amphetamine into the Acb inhibited the cocaine-like locomotor effects produced by Acb dopamine microinfusions, both intra-accumbal and intra-pallidal injections of CART peptide led to reduction in cocaine- and amphetamine-induced locomotor activity (Jaworski et al., 2003, 2008; Kim et al., 2003; Hubert et al., 2010). Correspondingly, CART depletion through intra-accumbal CART shRNA increased cocaine-mediated locomotion (Job and Kuhar, 2012), supporting an antagonistic property of Acb CART in the functions of cocaine and other psychostimulants.","tracks":[{"project":"TEST0","denotations":[{"id":"25352770-228-236-357739","span":{"begin":583,"end":587},"obj":"[\"14698680\"]"},{"id":"25352770-232-240-357740","span":{"begin":606,"end":610},"obj":"[\"18485497\"]"},{"id":"25352770-230-238-357741","span":{"begin":627,"end":631},"obj":"[\"19825396\"]"},{"id":"25352770-224-232-357742","span":{"begin":648,"end":652},"obj":"[\"23705073\"]"},{"id":"25352770-235-243-357743","span":{"begin":670,"end":674},"obj":"[\"22186082\"]"},{"id":"25352770-232-240-357744","span":{"begin":958,"end":962},"obj":"[\"19825396\"]"},{"id":"25352770-232-240-357745","span":{"begin":1354,"end":1358},"obj":"[\"14551286\"]"},{"id":"25352770-234-242-357746","span":{"begin":1360,"end":1364},"obj":"[\"18485497\"]"},{"id":"25352770-229-237-357747","span":{"begin":1378,"end":1382},"obj":"[\"14698680\"]"},{"id":"25352770-233-241-357748","span":{"begin":1399,"end":1403},"obj":"[\"19825396\"]"},{"id":"25352770-120-128-357749","span":{"begin":1526,"end":1530},"obj":"[\"23705073\"]"}],"attributes":[{"subj":"25352770-228-236-357739","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357740","pred":"source","obj":"TEST0"},{"subj":"25352770-230-238-357741","pred":"source","obj":"TEST0"},{"subj":"25352770-224-232-357742","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357743","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357744","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357745","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357746","pred":"source","obj":"TEST0"},{"subj":"25352770-229-237-357747","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357748","pred":"source","obj":"TEST0"},{"subj":"25352770-120-128-357749","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"25352770-14698680-357739","span":{"begin":583,"end":587},"obj":"14698680"},{"id":"25352770-18485497-357740","span":{"begin":606,"end":610},"obj":"18485497"},{"id":"25352770-19825396-357741","span":{"begin":627,"end":631},"obj":"19825396"},{"id":"25352770-23705073-357742","span":{"begin":648,"end":652},"obj":"23705073"},{"id":"25352770-22186082-357743","span":{"begin":670,"end":674},"obj":"22186082"},{"id":"25352770-19825396-357744","span":{"begin":958,"end":962},"obj":"19825396"},{"id":"25352770-14551286-357745","span":{"begin":1354,"end":1358},"obj":"14551286"},{"id":"25352770-18485497-357746","span":{"begin":1360,"end":1364},"obj":"18485497"},{"id":"25352770-14698680-357747","span":{"begin":1378,"end":1382},"obj":"14698680"},{"id":"25352770-19825396-357748","span":{"begin":1399,"end":1403},"obj":"19825396"},{"id":"25352770-23705073-357749","span":{"begin":1526,"end":1530},"obj":"23705073"}],"attributes":[{"subj":"25352770-14698680-357739","pred":"source","obj":"0_colil"},{"subj":"25352770-18485497-357740","pred":"source","obj":"0_colil"},{"subj":"25352770-19825396-357741","pred":"source","obj":"0_colil"},{"subj":"25352770-23705073-357742","pred":"source","obj":"0_colil"},{"subj":"25352770-22186082-357743","pred":"source","obj":"0_colil"},{"subj":"25352770-19825396-357744","pred":"source","obj":"0_colil"},{"subj":"25352770-14551286-357745","pred":"source","obj":"0_colil"},{"subj":"25352770-18485497-357746","pred":"source","obj":"0_colil"},{"subj":"25352770-14698680-357747","pred":"source","obj":"0_colil"},{"subj":"25352770-19825396-357748","pred":"source","obj":"0_colil"},{"subj":"25352770-23705073-357749","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"25352770-14698680-38284728","span":{"begin":583,"end":587},"obj":"14698680"},{"id":"25352770-18485497-38284729","span":{"begin":606,"end":610},"obj":"18485497"},{"id":"25352770-19825396-38284730","span":{"begin":627,"end":631},"obj":"19825396"},{"id":"25352770-23705073-38284731","span":{"begin":648,"end":652},"obj":"23705073"},{"id":"25352770-22186082-38284732","span":{"begin":670,"end":674},"obj":"22186082"},{"id":"25352770-19825396-38284733","span":{"begin":958,"end":962},"obj":"19825396"},{"id":"25352770-14551286-38284734","span":{"begin":1354,"end":1358},"obj":"14551286"},{"id":"25352770-18485497-38284735","span":{"begin":1360,"end":1364},"obj":"18485497"},{"id":"25352770-14698680-38284736","span":{"begin":1378,"end":1382},"obj":"14698680"},{"id":"25352770-19825396-38284737","span":{"begin":1399,"end":1403},"obj":"19825396"},{"id":"25352770-23705073-38284738","span":{"begin":1526,"end":1530},"obj":"23705073"}],"attributes":[{"subj":"25352770-14698680-38284728","pred":"source","obj":"2_test"},{"subj":"25352770-18485497-38284729","pred":"source","obj":"2_test"},{"subj":"25352770-19825396-38284730","pred":"source","obj":"2_test"},{"subj":"25352770-23705073-38284731","pred":"source","obj":"2_test"},{"subj":"25352770-22186082-38284732","pred":"source","obj":"2_test"},{"subj":"25352770-19825396-38284733","pred":"source","obj":"2_test"},{"subj":"25352770-14551286-38284734","pred":"source","obj":"2_test"},{"subj":"25352770-18485497-38284735","pred":"source","obj"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