PMC:4195273 / 60290-61303 JSONTXT

{"project":"TEST0","denotations":[{"id":"25352770-210-218-357733","span":{"begin":210,"end":214},"obj":"[\"15659233\"]"},{"id":"25352770-167-175-357734","span":{"begin":384,"end":388},"obj":"[\"17913892\"]"},{"id":"25352770-188-196-357735","span":{"begin":405,"end":409},"obj":"[\"23705073\"]"},{"id":"25352770-219-227-357736","span":{"begin":631,"end":635},"obj":"[\"17913892\"]"},{"id":"25352770-224-232-357737","span":{"begin":652,"end":656},"obj":"[\"23705073\"]"},{"id":"25352770-231-239-357738","span":{"begin":1007,"end":1011},"obj":"[\"17913892\"]"}],"text":"The anorexia elicited by intra-accumbal CART was more sustainable in freely fed compared to starved animals, highlighting the significance of fuel status on CART function in feeding modulation (Yang and Shieh, 2005). Furthermore, complementary to the overexpression experiments, RNA-interference has been employed to investigate the effects of CART depletion in rodents (Jean et al., 2007; Job and Kuhar, 2012). Tissue-specific CART knockdown in the Acb via intra-accumbal administration of short interfering RNA (siRNA) or short hairpin (shRNA) against CART mRNA induced body weight gain and hyperphagia in fed mice (Jean et al., 2007; Job and Kuhar, 2012), as well as abolishing the anorectic effects of serotonin (5-hydroxytryptamine, 5-HT) 4 receptor (5-HT4R) stimulation as well as 3,4-N-methylenedioxymethamphetamine (MDMA, ecstasy) treatment in starved mice, further denoting the potential role of Acb CART in mediating the appetite suppressant properties in models of anorexia nervosa (Jean et al., 2007)."}

{"project":"0_colil","denotations":[{"id":"25352770-15659233-357733","span":{"begin":210,"end":214},"obj":"15659233"},{"id":"25352770-17913892-357734","span":{"begin":384,"end":388},"obj":"17913892"},{"id":"25352770-23705073-357735","span":{"begin":405,"end":409},"obj":"23705073"},{"id":"25352770-17913892-357736","span":{"begin":631,"end":635},"obj":"17913892"},{"id":"25352770-23705073-357737","span":{"begin":652,"end":656},"obj":"23705073"},{"id":"25352770-17913892-357738","span":{"begin":1007,"end":1011},"obj":"17913892"}],"text":"The anorexia elicited by intra-accumbal CART was more sustainable in freely fed compared to starved animals, highlighting the significance of fuel status on CART function in feeding modulation (Yang and Shieh, 2005). Furthermore, complementary to the overexpression experiments, RNA-interference has been employed to investigate the effects of CART depletion in rodents (Jean et al., 2007; Job and Kuhar, 2012). Tissue-specific CART knockdown in the Acb via intra-accumbal administration of short interfering RNA (siRNA) or short hairpin (shRNA) against CART mRNA induced body weight gain and hyperphagia in fed mice (Jean et al., 2007; Job and Kuhar, 2012), as well as abolishing the anorectic effects of serotonin (5-hydroxytryptamine, 5-HT) 4 receptor (5-HT4R) stimulation as well as 3,4-N-methylenedioxymethamphetamine (MDMA, ecstasy) treatment in starved mice, further denoting the potential role of Acb CART in mediating the appetite suppressant properties in models of anorexia nervosa (Jean et al., 2007)."}

{"project":"2_test","denotations":[{"id":"25352770-15659233-38284722","span":{"begin":210,"end":214},"obj":"15659233"},{"id":"25352770-17913892-38284723","span":{"begin":384,"end":388},"obj":"17913892"},{"id":"25352770-23705073-38284724","span":{"begin":405,"end":409},"obj":"23705073"},{"id":"25352770-17913892-38284725","span":{"begin":631,"end":635},"obj":"17913892"},{"id":"25352770-23705073-38284726","span":{"begin":652,"end":656},"obj":"23705073"},{"id":"25352770-17913892-38284727","span":{"begin":1007,"end":1011},"obj":"17913892"}],"text":"The anorexia elicited by intra-accumbal CART was more sustainable in freely fed compared to starved animals, highlighting the significance of fuel status on CART function in feeding modulation (Yang and Shieh, 2005). Furthermore, complementary to the overexpression experiments, RNA-interference has been employed to investigate the effects of CART depletion in rodents (Jean et al., 2007; Job and Kuhar, 2012). Tissue-specific CART knockdown in the Acb via intra-accumbal administration of short interfering RNA (siRNA) or short hairpin (shRNA) against CART mRNA induced body weight gain and hyperphagia in fed mice (Jean et al., 2007; Job and Kuhar, 2012), as well as abolishing the anorectic effects of serotonin (5-hydroxytryptamine, 5-HT) 4 receptor (5-HT4R) stimulation as well as 3,4-N-methylenedioxymethamphetamine (MDMA, ecstasy) treatment in starved mice, further denoting the potential role of Acb CART in mediating the appetite suppressant properties in models of anorexia nervosa (Jean et al., 2007)."}