PMC:4195273 / 5346-6504
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"While a specific CART receptor(s) has not been identified to date, there is strong evidence that CART signaling can be blocked by pertussis toxin (PTX), indicative of the involvement of an inhibitory G-protein-coupling receptor that couples to Gi/o proteins (Yermolaieva et al., 2001; Lakatos et al., 2005; Sen et al., 2007). For example, CART I (55–102) has been described to inhibit voltage-gated L-type Ca2+ channels in hippocampal neurons, an effect that was blocked by treatment with PTX (Yermolaieva et al., 2001). Furthermore, central administration of CART I (55–102) stimulated the phosphorylation of cyclic AMP-response-element-binding protein (CREB) in CRH neurons in the PVN of fasted and fed rats (Sarkar et al., 2004), which again is classified as a PTX-sensitive mechanism. Finally, CART I (55–102) application activated extracellular signal-regulated kinase (ERK) phosphorylation in the rodent pituitary-derived cell lines, AtT20 and GH3, and such CART-induced effects were attenuated by a MEK kinase inhibitor as well as pre-treatment with PTX (Lakatos et al., 2005), further supporting the mediation of CART action by inhibitory G proteins.","tracks":[{"project":"TEST0","denotations":[{"id":"25352770-232-240-357269","span":{"begin":279,"end":283},"obj":"[\"11567037\"]"},{"id":"25352770-234-242-357270","span":{"begin":301,"end":305},"obj":"[\"15908120\"]"},{"id":"25352770-227-235-357271","span":{"begin":319,"end":323},"obj":"[\"17569753\"]"},{"id":"25352770-188-196-357272","span":{"begin":514,"end":518},"obj":"[\"11567037\"]"},{"id":"25352770-205-213-357273","span":{"begin":726,"end":730},"obj":"[\"14759497\"]"},{"id":"25352770-228-236-357274","span":{"begin":1078,"end":1082},"obj":"[\"15908120\"]"}],"attributes":[{"subj":"25352770-232-240-357269","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357270","pred":"source","obj":"TEST0"},{"subj":"25352770-227-235-357271","pred":"source","obj":"TEST0"},{"subj":"25352770-188-196-357272","pred":"source","obj":"TEST0"},{"subj":"25352770-205-213-357273","pred":"source","obj":"TEST0"},{"subj":"25352770-228-236-357274","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"25352770-11567037-357269","span":{"begin":279,"end":283},"obj":"11567037"},{"id":"25352770-15908120-357270","span":{"begin":301,"end":305},"obj":"15908120"},{"id":"25352770-17569753-357271","span":{"begin":319,"end":323},"obj":"17569753"},{"id":"25352770-11567037-357272","span":{"begin":514,"end":518},"obj":"11567037"},{"id":"25352770-14759497-357273","span":{"begin":726,"end":730},"obj":"14759497"},{"id":"25352770-15908120-357274","span":{"begin":1078,"end":1082},"obj":"15908120"}],"attributes":[{"subj":"25352770-11567037-357269","pred":"source","obj":"0_colil"},{"subj":"25352770-15908120-357270","pred":"source","obj":"0_colil"},{"subj":"25352770-17569753-357271","pred":"source","obj":"0_colil"},{"subj":"25352770-11567037-357272","pred":"source","obj":"0_colil"},{"subj":"25352770-14759497-357273","pred":"source","obj":"0_colil"},{"subj":"25352770-15908120-357274","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"25352770-11567037-38284258","span":{"begin":279,"end":283},"obj":"11567037"},{"id":"25352770-15908120-38284259","span":{"begin":301,"end":305},"obj":"15908120"},{"id":"25352770-17569753-38284260","span":{"begin":319,"end":323},"obj":"17569753"},{"id":"25352770-11567037-38284261","span":{"begin":514,"end":518},"obj":"11567037"},{"id":"25352770-14759497-38284262","span":{"begin":726,"end":730},"obj":"14759497"},{"id":"25352770-15908120-38284263","span":{"begin":1078,"end":1082},"obj":"15908120"}],"attributes":[{"subj":"25352770-11567037-38284258","pred":"source","obj":"2_test"},{"subj":"25352770-15908120-38284259","pred":"source","obj":"2_test"},{"subj":"25352770-17569753-38284260","pred":"source","obj":"2_test"},{"subj":"25352770-11567037-38284261","pred":"source","obj":"2_test"},{"subj":"25352770-14759497-38284262","pred":"source","obj":"2_test"},{"subj":"25352770-15908120-38284263","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec93a9","default":true},{"id":"0_colil","color":"#93c3ec"},{"id":"2_test","color":"#ddec93"}]}]}}