PMC:4195273 / 46430-48511
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"CSF, cerebrospinal fluid; DIO, diet-induced obese; HFD, high fat diet; BAT, brown adipose tissue; i.c.v., intracerebroventricular; i.c., intracisternal; LV, lateral ventricle; 3V, third ventricle; 4V, fourth ventricle; Acb, nucleus accumbens; AcbSh, nucleus accumbens shell; AHA, anterior hypothalamic area; Arc, arcuate nucleus; DMH, dorsomedial nucleus; LHA, lateral hypothalamic area; NTS, nucleus of the solitary tract; PBN, parabrachial nucleus; PVN, paraventricular nucleus; SON, supraoptic nucleus; VMH, ventromedial hypothalamic nucleus.\nEffects on body weight described where results presented, otherwise either unaffected or information unavailable.\nEffects on locomotor behavior described where results presented, otherwise either unaffected or information unavailable.\na Cerebral aqueduct occlusion to interrupt forebrain-hindbrain CSF flow.\nb Inhibition of gastric function (suppression of gastric acid secretion and gastric emptying); inhibition of gastric acid secretion remained in vagotomized animals; inhibition of gastric acid secretion blocked by pretreatment with central administration of CRF receptor antagonist α-helical CRF9-41.\nc Inhibition of gastric function (suppression of gastric emptying); inhibition of gastric emptying blocked by pretreatment with central administration of CRF receptor antagonist α-helical CRF9-41; CART-induced inhibition of gastric emptying proposed unlikely to contribute to CART-mediated inhibition of food intake.\nd Acute administration through repeated injections and chronic overexpression using stereotactically targeted gene transfer.\ne Chronic overexpression using recombinant adeno-associated virus vector containing rat CART cDNA.\nf ↑ Blood glucose levels; hyperglycemic response not altered by GLP-1R blockade in animals pre-treated with GLP-1R antagonist (exendin-9-39).\ng Induction of Fos expression in the PVN, DMH, SON and Arc (hypothalamus), central nucleus of amygdala (cerebrum), PBN and NTS (hindbrain).\nh Induction of Fos expression in NTS neurons.\ni ↑ UCP-1 expression thermogenic capacity in BAT.","divisions":[{"label":"p","span":{"begin":0,"end":545}},{"label":"p","span":{"begin":546,"end":659}},{"label":"p","span":{"begin":660,"end":780}},{"label":"footnote","span":{"begin":781,"end":854}},{"label":"label","span":{"begin":781,"end":782}},{"label":"p","span":{"begin":784,"end":854}},{"label":"footnote","span":{"begin":855,"end":1155}},{"label":"label","span":{"begin":855,"end":856}},{"label":"p","span":{"begin":858,"end":1155}},{"label":"footnote","span":{"begin":1156,"end":1473}},{"label":"label","span":{"begin":1156,"end":1157}},{"label":"p","span":{"begin":1159,"end":1473}},{"label":"footnote","span":{"begin":1474,"end":1599}},{"label":"label","span":{"begin":1474,"end":1475}},{"label":"p","span":{"begin":1477,"end":1599}},{"label":"footnote","span":{"begin":1600,"end":1699}},{"label":"label","span":{"begin":1600,"end":1601}},{"label":"p","span":{"begin":1603,"end":1699}},{"label":"footnote","span":{"begin":1700,"end":1842}},{"label":"label","span":{"begin":1700,"end":1701}},{"label":"p","span":{"begin":1703,"end":1842}},{"label":"footnote","span":{"begin":1843,"end":1983}},{"label":"label","span":{"begin":1843,"end":1844}},{"label":"p","span":{"begin":1846,"end":1983}},{"label":"footnote","span":{"begin":1984,"end":2030}},{"label":"label","span":{"begin":1984,"end":1985}},{"label":"p","span":{"begin":1987,"end":2030}},{"label":"label","span":{"begin":2031,"end":2032}}],"tracks":[]}