PMC:4195273 / 24693-26180 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"Despite purported relevance of CART in the modulation of gastrointestinal (GI) function, it is at present unclear the definite roles of enteric CART in intestinal motility, satiety and feeding behavior (Okumura et al., 2000; Ekblad et al., 2003; Smedh and Moran, 2003; Tebbe et al., 2004). Convincing evidence supporting the GI effects of CART have been provided by independent investigations, where central injections of CART in rodents elicited an anorexigenic response accompanied by the inhibition of gastric emptying and gastric acid secretion (Okumura et al., 2000; Asakawa et al., 2001; Smedh and Moran, 2003), while colonic motility measured by colonic transit time was accelerated (Tebbe et al., 2004). Contrary to a local ENS effect, such alterations in GI functions were indicated to be conveyed through CART acting in the CNS (Okumura et al., 2000; Ekblad et al., 2003; Smedh and Moran, 2003, 2006; Tebbe et al., 2004), as intraperitoneal (i.p.) CART administration failed to reduce food consumption or reproduce similar gastric responses (Okumura et al., 2000; Tebbe et al., 2004; Skibicka et al., 2009). Furthermore, pretreatment with central injection of CRH receptor antagonist prior to central CART administration completely abolished the CART-induced gastric effects, suggesting a central CART-directed CNS modulation of the digestive tract behavioral motor functions via CRH-dependent mechanisms (Okumura et al., 2000; Smedh and Moran, 2003, 2006; Tebbe et al., 2004).","tracks":[{"project":"TEST0","denotations":[{"id":"25352770-219-227-357450","span":{"begin":219,"end":223},"obj":"[\"10919272\"]"},{"id":"25352770-232-240-357451","span":{"begin":240,"end":244},"obj":"[\"14507354\"]"},{"id":"25352770-235-243-357452","span":{"begin":263,"end":267},"obj":"[\"12468444\"]"},{"id":"25352770-229-237-357453","span":{"begin":283,"end":287},"obj":"[\"15306004\"]"},{"id":"25352770-230-238-357454","span":{"begin":566,"end":570},"obj":"[\"10919272\"]"},{"id":"25352770-234-242-357455","span":{"begin":588,"end":592},"obj":"[\"11561216\"]"},{"id":"25352770-233-241-357456","span":{"begin":611,"end":615},"obj":"[\"12468444\"]"},{"id":"25352770-233-241-357457","span":{"begin":705,"end":709},"obj":"[\"15306004\"]"},{"id":"25352770-143-151-357458","span":{"begin":855,"end":859},"obj":"[\"10919272\"]"},{"id":"25352770-164-172-357459","span":{"begin":876,"end":880},"obj":"[\"14507354\"]"},{"id":"25352770-187-195-357460","span":{"begin":899,"end":903},"obj":"[\"12468444\"]"},{"id":"25352770-193-201-357461","span":{"begin":905,"end":909},"obj":"[\"16455772\"]"},{"id":"25352770-213-221-357462","span":{"begin":925,"end":929},"obj":"[\"15306004\"]"},{"id":"25352770-110-118-357463","span":{"begin":1068,"end":1072},"obj":"[\"10919272\"]"},{"id":"25352770-130-138-357464","span":{"begin":1088,"end":1092},"obj":"[\"15306004\"]"},{"id":"25352770-153-161-357465","span":{"begin":1111,"end":1115},"obj":"[\"19474324\"]"},{"id":"25352770-232-240-357466","span":{"begin":1432,"end":1436},"obj":"[\"10919272\"]"},{"id":"25352770-224-232-357467","span":{"begin":1455,"end":1459},"obj":"[\"12468444\"]"},{"id":"25352770-230-238-357468","span":{"begin":1461,"end":1465},"obj":"[\"16455772\"]"},{"id":"25352770-229-237-357469","span":{"begin":1481,"end":1485},"obj":"[\"15306004\"]"}],"attributes":[{"subj":"25352770-219-227-357450","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357451","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357452","pred":"source","obj":"TEST0"},{"subj":"25352770-229-237-357453","pred":"source","obj":"TEST0"},{"subj":"25352770-230-238-357454","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357455","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357456","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357457","pred":"source","obj":"TEST0"},{"subj":"25352770-143-151-357458","pred":"source","obj":"TEST0"},{"subj":"25352770-164-172-357459","pred":"source","obj":"TEST0"},{"subj":"25352770-187-195-357460","pred":"source","obj":"TEST0"},{"subj":"25352770-193-201-357461","pred":"source","obj":"TEST0"},{"subj":"25352770-213-221-357462","pred":"source","obj":"TEST0"},{"subj":"25352770-110-118-357463","pred":"source","obj":"TEST0"},{"subj":"25352770-130-138-357464","pred":"source","obj":"TEST0"},{"subj":"25352770-153-161-357465","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357466","pred":"source","obj":"TEST0"},{"subj":"25352770-224-232-357467","pred":"source","obj":"TEST0"},{"subj":"25352770-230-238-357468","pred":"source","obj":"TEST0"},{"subj":"25352770-229-237-357469","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"25352770-10919272-357450","span":{"begin":219,"end":223},"obj":"10919272"},{"id":"25352770-14507354-357451","span":{"begin":240,"end":244},"obj":"14507354"},{"id":"25352770-12468444-357452","span":{"begin":263,"end":267},"obj":"12468444"},{"id":"25352770-15306004-357453","span":{"begin":283,"end":287},"obj":"15306004"},{"id":"25352770-10919272-357454","span":{"begin":566,"end":570},"obj":"10919272"},{"id":"25352770-11561216-357455","span":{"begin":588,"end":592},"obj":"11561216"},{"id":"25352770-12468444-357456","span":{"begin":611,"end":615},"obj":"12468444"},{"id":"25352770-15306004-357457","span":{"begin":705,"end":709},"obj":"15306004"},{"id":"25352770-10919272-357458","span":{"begin":855,"end":859},"obj":"10919272"},{"id":"25352770-14507354-357459","span":{"begin":876,"end":880},"obj":"14507354"},{"id":"25352770-12468444-357460","span":{"begin":899,"end":903},"obj":"12468444"},{"id":"25352770-16455772-357461","span":{"begin":905,"end":909},"obj":"16455772"},{"id":"25352770-15306004-357462","span":{"begin":925,"end":929},"obj":"15306004"},{"id":"25352770-10919272-357463","span":{"begin":1068,"end":1072},"obj":"10919272"},{"id":"25352770-15306004-357464","span":{"begin":1088,"end":1092},"obj":"15306004"},{"id":"25352770-19474324-357465","span":{"begin":1111,"end":1115},"obj":"19474324"},{"id":"25352770-10919272-357466","span":{"begin":1432,"end":1436},"obj":"10919272"},{"id":"25352770-12468444-357467","span":{"begin":1455,"end":1459},"obj":"12468444"},{"id":"25352770-16455772-357468","span":{"begin":1461,"end":1465},"obj":"16455772"},{"id":"25352770-15306004-357469","span":{"begin":1481,"end":1485},"obj":"15306004"}],"attributes":[{"subj":"25352770-10919272-357450","pred":"source","obj":"0_colil"},{"subj":"25352770-14507354-357451","pred":"source","obj":"0_colil"},{"subj":"25352770-12468444-357452","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