PMC:4195273 / 10957-12078 JSONTXT

{"project":"TEST0","denotations":[{"id":"25352770-235-243-357336","span":{"begin":303,"end":307},"obj":"[\"2417205\"]"},{"id":"25352770-231-239-357337","span":{"begin":326,"end":330},"obj":"[\"10196541\"]"},{"id":"25352770-231-239-357338","span":{"begin":352,"end":356},"obj":"[\"12154382\"]"},{"id":"25352770-207-215-357339","span":{"begin":566,"end":570},"obj":"[\"7984236\"]"},{"id":"25352770-230-238-357340","span":{"begin":589,"end":593},"obj":"[\"8625930\"]"},{"id":"25352770-225-233-357341","span":{"begin":611,"end":615},"obj":"[\"8923837\"]"},{"id":"25352770-235-243-357342","span":{"begin":715,"end":719},"obj":"[\"10766253\"]"},{"id":"25352770-191-199-357343","span":{"begin":913,"end":917},"obj":"[\"10766253\"]"},{"id":"25352770-195-203-357344","span":{"begin":1115,"end":1119},"obj":"[\"11196643\"]"}],"text":"Two sets of neurons with reciprocal metabolic effects reside in the Arc, namely the orexigenic neuropeptide Y (NPY)/AgRP neurons which promote food intake and reduce energy expenditure, and the adjacent anorexigenic POMC/CART neurons that inhibit food intake and increase energy expenditure (Chronwall, 1985; Elmquist et al., 1998; Barsh and Schwartz, 2002). In response to circulating hormones, such as leptin and insulin that are secreted from adipose tissues and the pancreas, respectively, with a plasma level proportionate to body adipose stores (Zhang et al., 1994; McGregor et al., 1996; Ostlund et al., 1996), hypothalamic expression of the two sets of neurons is differentially regulated (Schwartz et al., 2000). For instance, leptin and insulin levels are reduced following food deprivation that lowers body fat stores, which inhibits POMC/CART neurons and stimulates NPY/AgRP neurons (Schwartz et al., 2000). In addition, the NPY/AgRP neurons are also subject to activation by the circulating orexigenic peptide ghrelin released from the stomach with peak levels before meal initiation (Nakazato et al., 2001)."}

{"project":"0_colil","denotations":[{"id":"25352770-2417205-357336","span":{"begin":303,"end":307},"obj":"2417205"},{"id":"25352770-10196541-357337","span":{"begin":326,"end":330},"obj":"10196541"},{"id":"25352770-12154382-357338","span":{"begin":352,"end":356},"obj":"12154382"},{"id":"25352770-7984236-357339","span":{"begin":566,"end":570},"obj":"7984236"},{"id":"25352770-8625930-357340","span":{"begin":589,"end":593},"obj":"8625930"},{"id":"25352770-8923837-357341","span":{"begin":611,"end":615},"obj":"8923837"},{"id":"25352770-10766253-357342","span":{"begin":715,"end":719},"obj":"10766253"},{"id":"25352770-10766253-357343","span":{"begin":913,"end":917},"obj":"10766253"},{"id":"25352770-11196643-357344","span":{"begin":1115,"end":1119},"obj":"11196643"}],"text":"Two sets of neurons with reciprocal metabolic effects reside in the Arc, namely the orexigenic neuropeptide Y (NPY)/AgRP neurons which promote food intake and reduce energy expenditure, and the adjacent anorexigenic POMC/CART neurons that inhibit food intake and increase energy expenditure (Chronwall, 1985; Elmquist et al., 1998; Barsh and Schwartz, 2002). In response to circulating hormones, such as leptin and insulin that are secreted from adipose tissues and the pancreas, respectively, with a plasma level proportionate to body adipose stores (Zhang et al., 1994; McGregor et al., 1996; Ostlund et al., 1996), hypothalamic expression of the two sets of neurons is differentially regulated (Schwartz et al., 2000). For instance, leptin and insulin levels are reduced following food deprivation that lowers body fat stores, which inhibits POMC/CART neurons and stimulates NPY/AgRP neurons (Schwartz et al., 2000). In addition, the NPY/AgRP neurons are also subject to activation by the circulating orexigenic peptide ghrelin released from the stomach with peak levels before meal initiation (Nakazato et al., 2001)."}

{"project":"2_test","denotations":[{"id":"25352770-2417205-38284325","span":{"begin":303,"end":307},"obj":"2417205"},{"id":"25352770-10196541-38284326","span":{"begin":326,"end":330},"obj":"10196541"},{"id":"25352770-12154382-38284327","span":{"begin":352,"end":356},"obj":"12154382"},{"id":"25352770-7984236-38284328","span":{"begin":566,"end":570},"obj":"7984236"},{"id":"25352770-8625930-38284329","span":{"begin":589,"end":593},"obj":"8625930"},{"id":"25352770-8923837-38284330","span":{"begin":611,"end":615},"obj":"8923837"},{"id":"25352770-10766253-38284331","span":{"begin":715,"end":719},"obj":"10766253"},{"id":"25352770-10766253-38284332","span":{"begin":913,"end":917},"obj":"10766253"},{"id":"25352770-11196643-38284333","span":{"begin":1115,"end":1119},"obj":"11196643"}],"text":"Two sets of neurons with reciprocal metabolic effects reside in the Arc, namely the orexigenic neuropeptide Y (NPY)/AgRP neurons which promote food intake and reduce energy expenditure, and the adjacent anorexigenic POMC/CART neurons that inhibit food intake and increase energy expenditure (Chronwall, 1985; Elmquist et al., 1998; Barsh and Schwartz, 2002). In response to circulating hormones, such as leptin and insulin that are secreted from adipose tissues and the pancreas, respectively, with a plasma level proportionate to body adipose stores (Zhang et al., 1994; McGregor et al., 1996; Ostlund et al., 1996), hypothalamic expression of the two sets of neurons is differentially regulated (Schwartz et al., 2000). For instance, leptin and insulin levels are reduced following food deprivation that lowers body fat stores, which inhibits POMC/CART neurons and stimulates NPY/AgRP neurons (Schwartz et al., 2000). In addition, the NPY/AgRP neurons are also subject to activation by the circulating orexigenic peptide ghrelin released from the stomach with peak levels before meal initiation (Nakazato et al., 2001)."}