PMC:4182838 / 24203-25686 JSONTXT

{"project":"NEUROSES","denotations":[{"id":"T689","span":{"begin":41,"end":45},"obj":"PATO_0001309"},{"id":"T690","span":{"begin":41,"end":45},"obj":"PATO_0000165"},{"id":"T691","span":{"begin":116,"end":126},"obj":"PATO_0000990"},{"id":"T692","span":{"begin":547,"end":557},"obj":"PATO_0000990"},{"id":"T693","span":{"begin":770,"end":780},"obj":"PATO_0000990"},{"id":"T694","span":{"begin":325,"end":334},"obj":"PATO_0000470"},{"id":"T695","span":{"begin":355,"end":364},"obj":"PATO_0000470"},{"id":"T696","span":{"begin":457,"end":460},"obj":"CHEBI_60614"},{"id":"T697","span":{"begin":709,"end":712},"obj":"CHEBI_60614"},{"id":"T698","span":{"begin":861,"end":864},"obj":"CHEBI_60614"},{"id":"T699","span":{"begin":987,"end":990},"obj":"CHEBI_60614"},{"id":"T700","span":{"begin":1307,"end":1310},"obj":"CHEBI_60614"},{"id":"T701","span":{"begin":457,"end":460},"obj":"CHEBI_35782"},{"id":"T702","span":{"begin":709,"end":712},"obj":"CHEBI_35782"},{"id":"T703","span":{"begin":861,"end":864},"obj":"CHEBI_35782"},{"id":"T704","span":{"begin":987,"end":990},"obj":"CHEBI_35782"},{"id":"T705","span":{"begin":1307,"end":1310},"obj":"CHEBI_35782"},{"id":"T706","span":{"begin":457,"end":460},"obj":"CHEBI_53266"},{"id":"T707","span":{"begin":709,"end":712},"obj":"CHEBI_53266"},{"id":"T708","span":{"begin":861,"end":864},"obj":"CHEBI_53266"},{"id":"T709","span":{"begin":987,"end":990},"obj":"CHEBI_53266"},{"id":"T710","span":{"begin":1307,"end":1310},"obj":"CHEBI_53266"},{"id":"T711","span":{"begin":457,"end":460},"obj":"CHEBI_18361"},{"id":"T712","span":{"begin":709,"end":712},"obj":"CHEBI_18361"},{"id":"T713","span":{"begin":861,"end":864},"obj":"CHEBI_18361"},{"id":"T714","span":{"begin":987,"end":990},"obj":"CHEBI_18361"},{"id":"T715","span":{"begin":1307,"end":1310},"obj":"CHEBI_18361"},{"id":"T716","span":{"begin":473,"end":481},"obj":"PATO_0000762"},{"id":"T717","span":{"begin":473,"end":481},"obj":"PATO_0001624"},{"id":"T718","span":{"begin":1449,"end":1460},"obj":"PATO_0001624"},{"id":"T719","span":{"begin":619,"end":623},"obj":"PATO_0000469"},{"id":"T720","span":{"begin":701,"end":708},"obj":"PATO_0000764"},{"id":"T721","span":{"begin":853,"end":860},"obj":"PATO_0000764"},{"id":"T722","span":{"begin":979,"end":986},"obj":"PATO_0000764"},{"id":"T723","span":{"begin":948,"end":955},"obj":"PATO_0000462"},{"id":"T724","span":{"begin":1146,"end":1151},"obj":"PATO_0000694"},{"id":"T725","span":{"begin":1214,"end":1221},"obj":"PATO_0000467"}],"text":"Antisaccade inhibition\nThis is the first time antisaccade inhibition has been examined in 22q11DS. Our results were consistent with reports from other clinical populations [schizophrenia [25], first episode psychosis [35]] indicating that 22q11DS participants were less able to inhibit an automatic pre-potent response (i.e. increased antisaccade error). Increased antisaccade error in 22q11DS may reflect the inhibitory demands of the task and support our PPI findings of impaired controlled attention processes in 22q11DS. Our findings are also consistent with studies that show poor antisaccade performance in ultra-high risk for schizophrenia [36] and first episode schizophrenia groups [37].\nOur passive PPI task was uncorrelated with the antisaccade task. This is consistent with previous studies in schizophrenia that show no association between passive PPI and antisaccade accuracy [38]. We partly concur with Swerdlow et al. [39] that the absence of association between passive PPI and antisaccade indicates that the measures are partly \"dissociable and non-redundant\" (p336) measures of information processing, resembling tasks tapping early versus late portions of the information processing chain. The present study shows poorer antisaccade accuracy, as well as attention-modulation deficits in PPI in 22q11DS. Taken together, these findings suggest a more cortical, in particular prefrontal, than subcortical (i.e. superior collicular) dysfunction in our 22q11DS sample."}

{"project":"2_test","denotations":[{"id":"25279014-11206670-62820151","span":{"begin":188,"end":190},"obj":"11206670"},{"id":"25279014-15476684-62820152","span":{"begin":218,"end":220},"obj":"15476684"},{"id":"25279014-17656071-62820153","span":{"begin":648,"end":650},"obj":"17656071"},{"id":"25279014-1546118-62820154","span":{"begin":692,"end":694},"obj":"1546118"},{"id":"25279014-15725421-62820155","span":{"begin":891,"end":893},"obj":"15725421"},{"id":"25279014-18568339-62820156","span":{"begin":935,"end":937},"obj":"18568339"}],"text":"Antisaccade inhibition\nThis is the first time antisaccade inhibition has been examined in 22q11DS. Our results were consistent with reports from other clinical populations [schizophrenia [25], first episode psychosis [35]] indicating that 22q11DS participants were less able to inhibit an automatic pre-potent response (i.e. increased antisaccade error). Increased antisaccade error in 22q11DS may reflect the inhibitory demands of the task and support our PPI findings of impaired controlled attention processes in 22q11DS. Our findings are also consistent with studies that show poor antisaccade performance in ultra-high risk for schizophrenia [36] and first episode schizophrenia groups [37].\nOur passive PPI task was uncorrelated with the antisaccade task. This is consistent with previous studies in schizophrenia that show no association between passive PPI and antisaccade accuracy [38]. We partly concur with Swerdlow et al. [39] that the absence of association between passive PPI and antisaccade indicates that the measures are partly \"dissociable and non-redundant\" (p336) measures of information processing, resembling tasks tapping early versus late portions of the information processing chain. The present study shows poorer antisaccade accuracy, as well as attention-modulation deficits in PPI in 22q11DS. Taken together, these findings suggest a more cortical, in particular prefrontal, than subcortical (i.e. superior collicular) dysfunction in our 22q11DS sample."}