PMC:4167518 / 23952-25035 JSONTXT

{"project":"2_test","denotations":[{"id":"25299150-12110844-6059468","span":{"begin":155,"end":157},"obj":"12110844"},{"id":"25299150-14564349-6059468","span":{"begin":155,"end":157},"obj":"14564349"},{"id":"25299150-18778489-6059468","span":{"begin":155,"end":157},"obj":"18778489"},{"id":"25299150-21930123-6059468","span":{"begin":155,"end":157},"obj":"21930123"},{"id":"25299150-23612257-6059469","span":{"begin":197,"end":199},"obj":"23612257"},{"id":"25299150-12110844-6059470","span":{"begin":546,"end":548},"obj":"12110844"},{"id":"25299150-12110844-6059471","span":{"begin":720,"end":722},"obj":"12110844"},{"id":"25299150-16784537-6059472","span":{"begin":728,"end":730},"obj":"16784537"},{"id":"25299150-12110844-6059473","span":{"begin":803,"end":805},"obj":"12110844"},{"id":"25299150-22227561-6059474","span":{"begin":807,"end":809},"obj":"22227561"},{"id":"25299150-19940503-6059475","span":{"begin":1079,"end":1081},"obj":"19940503"}],"text":"The case–control association in our dataset does not support the influence of ADAM33-V4C/G or ADAM33-S1c.710G/A in asthma, contrary to some previous work [27–30] and consistent with other studies [68]. ADAM33-V4*C allele was nevertheless marginally over transmitted to Madeira asthmatics, as suggested by TDT analysis (1.8-fold risk for overall asthma, 2.4-fold risk for persistent asthma and 4-fold risk for mild asthma). A similar trend of association was seen in Caucasian children with asthma and bronchial responsiveness (p-value = 0.0959) [27]. Located at 3’-UTR, ADAM33-V4C/G SNP may influence the expression of its encoded desintegrin and metallopeptidase domain 33 in airway smooth muscle and lung fibroblasts [27, 69, 70] thus playing a role on airway remodeling and bronchial responsiveness [27, 71]. In addition, our study associates ADAM33-V4*CC to a wheal size ≥ 10 mm both in Dermatophagoides pteronyssinus and Blomia tropicalis, in accordance with a previous study relating ADAM33-V4*CC to high levels of IgE against Blomia tropicalis (Z score: 2.089, p = 0.03) [72]."}