PMC:4161609 / 18531-19184 JSONTXT

{"project":"2_test","denotations":[{"id":"25228816-17075276-55570438","span":{"begin":258,"end":260},"obj":"17075276"},{"id":"25228816-18384429-55570439","span":{"begin":323,"end":325},"obj":"18384429"}],"text":"Among the symptoms of asthma, the frequency of daytime sputum was correlated with FeNO. Interleukin 13, a pleiotropic Th2 cytokine that has been shown to be central to the pathogenesis of asthma, induces goblet cell hyperplasia and increased mucus secretion.15 It also induces nitric oxide synthase in bronchial epithelium,16 resulting in increased breath NO levels. Although increased airway secretion is not a specific phenomenon for Th2-dominant or eosinophilic inflammation, persistent hypersecretion resistant to pharmacotherapy in asthmatic patients may be a key sign that suggests intense eosinophilic inflammation remaining in the lower airways."}