PMC:4159494 / 2595-3824 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4159494","sourcedb":"PMC","sourceid":"4159494","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4159494","text":"Whether abnormalities in body composition are related to losses of bone and muscle or increases in adipose tissue, these unfavorable changes are likely to impact health. We use the term “osteosarcopenic obesity” to describe the concurrent appearance of obesity in individuals with low bone and muscle mass. We hypothesize that this phenotype may be associated with poorer functional and metabolic outcomes than each of these conditions alone, ultimately affecting quality of life, morbidity risk, and survival (Fig. 1). In this paper, we discuss potential mechanisms, populations at risk, health outcomes, and countermeasures to osteosarcopenic obesity.\nFig. 1 Clinical implications of changes in body composition. Legend: Abnormal body composition is defined as abnormalities in the amount and/or distribution of tissues in the body. Examples include low muscle mass (sarcopenia), low bone mass/density (osteoporosis), high levels of adipose tissue (obesity), abnormal patterns of adipose tissue distribution (visceral adiposity), and a combination of these abnormalities. Metabolic disorders include but not limited to insulin resistance, decrease production of anabolic hormones, and inflammation. LOS, length of hospital stay","divisions":[{"label":"label","span":{"begin":654,"end":660}}],"tracks":[]}