PMC:4159494 / 23496-24861 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4159494","sourcedb":"PMC","sourceid":"4159494","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4159494","text":"In addition to each component’s individual implications, combined disorders can influence the development of even more adverse outcomes, and one disorder may cause another. For example, in addition to the separate side effects of sarcopenia and obesity, sarcopenic obese patients have a higher incidence of impaired function [72], diminished quality of life [43], knee osteoarthritis [73], falls, disability [29], and chemotherapy toxicity [1, 74] and shorter survival in cancer patients [75] in comparison to individuals with normal body composition; this is most likely due to the dual affliction of both low muscle mass and excess adiposity. Though obesity may have a protective role on osteoporosis [76], some research has suggested that a high body weight may actually perpetuate the development of osteoporosis [77]. A large examination of over 60,000 women reported that high body weight is not protective against fracture incidence, but may in fact be associated with ankle and upper leg fractures [78]. Furthermore, those with the most muscle wasting and lowest grip strength have much higher odds of having osteoporosis, fractures, or falls than those who have more muscle mass and strength [79]. Clearly, these conditions are interrelated, and the occurrence of one may aid in the development of another and thus lead to compounded clinical implications.","tracks":[]}