PMC:4159490 / 21467-25070
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4159490","sourcedb":"PMC","sourceid":"4159490","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4159490","text":"Weekly averaged daily physical activity was negatively associated with age in MHD patients in unadjusted analyses (Fig. 1a), as reported by Johansen et al. [22], and after adjustment for gender and diabetes mellitus (r = −0.342, p \u003c 0.004). In normal controls, weekly averaged daily physical activity was not correlated with age, whether unadjusted (Fig. 1b) or adjusted for gender (r = −0.224, p = 0.177). Daily physical activity correlated directly with MHD vintage in unadjusted analyses (Fig. 2) and with adjustment for age and gender or age, gender, and diabetes (Table 4). In unadjusted analyses, weekly averaged daily physical activity correlated with 6-MWT (Fig. 2), sit-to-stand, and stair-climbing time in MHD patients. In MHD patients, DPA correlated only with 6-MWT but not with sit-to-stand or stair-climbing after adjustment for age and gender or age, gender, and diabetes (Table 4). In normal subjects in unadjusted analyses, daily physical activity correlated directly with the 6-MWT (r = 0.345, p = 0.032) but not with adjustment for age and gender. In normals, daily physical activity did not correlate with either sit-to-stand or stair-climbing measurements in either unadjusted or adjusted analyses. As might be expected, in both unadjusted and adjusted analyses, averaged weekly daily physical activity was significantly associated with the daily physical activity analyzed for each day of the HD cycle as well as for percent time in sleep or marked physical inactivity or in moderate or greater physical activity (Table 4).\nFig. 1 Unadjusted correlation between weekly averaged daily physical activity (DPA) and age in MHD patients (a) and normal controls (b)\nFig. 2 Unadjusted correlation between weekly averaged daily physical activity (DPA) and 6-min walk test in MHD patients (a) and normal controls (b)\nTable 4 Correlations in MHD patients with weekly averaged accelerometer-measured daily physical activity and with the human activity profile (HAP) with no adjustments and with adjustment for covariates\nUnadjusted Age, gender adjusted Age, gender, diabetes adjusted\nR p Value R p Value R p Value\nCorrelations with accelerometer-measured daily physical activity\nVintage (months) 0.266 0.024 0.252 0.035 0.257 0.033\nHuman activity profile\n Maximum activity score 0.277 0.019 0.102 0.403 0.101 0.410\n Adjusted activity score 0.366 0.002 0.206 0.087 0.207 0.087\nTime spent by monitor readings (%)\n Sleep or marked physical inactivity −0.868 \u003c0.0001 −0.881 \u003c0.0001 −0.885 \u003c0.0001\n Light activity 0.745 \u003c0.0001 0.794 \u003c0.0001 0.796 \u003c0.0001\n ≥ Moderate activity 0.843 \u003c0.0001 0.816 \u003c0.0001 0.820 \u003c0.0001\nDay of HD 0.898 \u003c0.0001 0.881 \u003c0.0001 0.881 \u003c0.0001\n1-day-post-HD 0.948 \u003c0.0001 0.942 \u003c0.0001 0.942 \u003c0.0001\n2-days-post-HD 0.815 \u003c0.0001 0.819 \u003c0.0001 0.819 \u003c0.0001\n6-min walk distance (meters) 0.387 \u003c0.0001 0.258 0.031 0.263 0.029\nSit-to-stand test (no. cycles in 30 s) 0.268 0.023 0.148 0.221 0.148 0.226\nStair-climbing test (seconds per 22 stairs) −0.283 0.016 −0.112 0.358 −0.111 0.363\nCorrelations with human activity profile\nMaximum activity score vs.\n 6-min walk distance (meters) 0.628 \u003c0.0001 0.496 \u003c0.0001 0.480 \u003c0.0001\n Sit-to-stand test (no. cycles in 30 s) 0.623 \u003c0.0001 0.534 \u003c0.0001 0.533 \u003c0.0001\n Stair-climbing test (seconds per 22 stairs) −0.707 \u003c0.0001 −0.595 \u003c0.0001 −0.584 \u003c0.0001\nAdjusted activity score vs.\n 6-min walk distance (meters) 0.642 \u003c0.0001 0.523 \u003c0.0001 0.504 \u003c0.0001\n Sit-to-stand test (no. cycles in 30 s) 0.581 \u003c0.0001 0.481 \u003c0.0001 0.479 \u003c0.0001\n Stair-climbing test (seconds per 22 stairs) −0.608 \u003c0.0001 −0.454 =0.0001 −0.437 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