PMC:4157149 / 7656-8143 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4157149","sourcedb":"PMC","sourceid":"4157149","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4157149","text":"On the other hand, the gene might have pleiotropic effects on the environmental factor and the outcome, but the environment might not cause the outcome. For example, a CYP3A variant might, via estradiol levels, influence both age at menarche and breast cancer risk. Age at menarche might have no direct effect on breast cancer, so it does not mediate the effect of the CYP3A variant, but it remains a risk factor by acting as a marker for other mechanisms that affect disease (Figure 2).","tracks":[]}