PMC:4157147 / 1712-2621
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4157147","sourcedb":"PMC","sourceid":"4157147","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4157147","text":"Grainyhead-like 2 (GRHL2) is a mammalian homolog of Drosophila protein grainy head (GRH), which, along with GRHL1 and GRHL3, has a role in epithelial morphogenesis.1,2 This family of transcription factors controls the development and differentiation of multicellular epithelia by regulating genes germane to cell junction formation and proliferation.3,4 Biologically, GRHL2 contributes to formation of the epithelial barrier and wound healing, as well as neural-tube closure, maintenance of the mucociliary airway epithelium, and tumor suppression.5–11 GRHL2 (MIM 608576) has been shown to regulate TERT (MIM 187270) expression and to enhance proliferation of epidermal keratinocytes; it also impairs keratinocyte differentiation through transcription inhibition of genes clustered at the epidermal differentiation complex12 and regulates epithelial morphogenesis by establishing functional tight junctions.13","tracks":[{"project":"2_test","denotations":[{"id":"25152456-12888489-2045824","span":{"begin":166,"end":167},"obj":"12888489"},{"id":"25152456-15936265-2045824","span":{"begin":166,"end":167},"obj":"15936265"},{"id":"25152456-20978075-2045825","span":{"begin":352,"end":353},"obj":"20978075"},{"id":"25152456-22955271-2045825","span":{"begin":352,"end":353},"obj":"22955271"},{"id":"25152456-1909284-2045826","span":{"begin":550,"end":552},"obj":"1909284"},{"id":"25152456-18303052-2045826","span":{"begin":550,"end":552},"obj":"18303052"},{"id":"25152456-23943797-2045826","span":{"begin":550,"end":552},"obj":"23943797"},{"id":"25152456-23814079-2045826","span":{"begin":550,"end":552},"obj":"23814079"},{"id":"25152456-24375798-2045826","span":{"begin":550,"end":552},"obj":"24375798"},{"id":"25152456-24586629-2045826","span":{"begin":550,"end":552},"obj":"24586629"},{"id":"25152456-24068586-2045826","span":{"begin":550,"end":552},"obj":"24068586"},{"id":"25152456-23254293-2045827","span":{"begin":822,"end":824},"obj":"23254293"},{"id":"25152456-22696678-2045828","span":{"begin":907,"end":909},"obj":"22696678"}],"attributes":[{"subj":"25152456-12888489-2045824","pred":"source","obj":"2_test"},{"subj":"25152456-15936265-2045824","pred":"source","obj":"2_test"},{"subj":"25152456-20978075-2045825","pred":"source","obj":"2_test"},{"subj":"25152456-22955271-2045825","pred":"source","obj":"2_test"},{"subj":"25152456-1909284-2045826","pred":"source","obj":"2_test"},{"subj":"25152456-18303052-2045826","pred":"source","obj":"2_test"},{"subj":"25152456-23943797-2045826","pred":"source","obj":"2_test"},{"subj":"25152456-23814079-2045826","pred":"source","obj":"2_test"},{"subj":"25152456-24375798-2045826","pred":"source","obj":"2_test"},{"subj":"25152456-24586629-2045826","pred":"source","obj":"2_test"},{"subj":"25152456-24068586-2045826","pred":"source","obj":"2_test"},{"subj":"25152456-23254293-2045827","pred":"source","obj":"2_test"},{"subj":"25152456-22696678-2045828","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#baec93","default":true}]}]}}