PMC:4157146 / 45384-46375 JSONTXT

{"project":"2_test","denotations":[{"id":"25192045-24088566-2045911","span":{"begin":136,"end":138},"obj":"24088566"},{"id":"25192045-2974040-2045912","span":{"begin":386,"end":388},"obj":"2974040"},{"id":"25192045-9725897-2045912","span":{"begin":386,"end":388},"obj":"9725897"},{"id":"25192045-15064350-2045912","span":{"begin":386,"end":388},"obj":"15064350"},{"id":"25192045-24088566-2045913","span":{"begin":989,"end":991},"obj":"24088566"}],"text":"Recent work showing that the Chlamydomonas ortholog of CCDC151, ODA10, is not an integral ODA component but is required for ODA assembly53 add to growing evidence for the existence of an accessory complex to the ODA-DC in Chlamydomonas that is independent from the ODA-DC. This ODA-DC accessory complex is thought to be composed of three subunits: ODA10 in addition to ODA5 and ODA8.64–66 It can thus be considered unlikely that human CCDC151 is a structural component of the ODAs or the ODA-DCs themselves. Rather, the loss of CCDC114 and ARMC4 from CCDC151-mutated cilia and the direct interaction between CCDC151 and CCDC114 point to a role for CCDC151 in the assembly or other activities of the ODA docking complex. Chlamydomonas studies have shown that ODA10/CCDC151 might have a role in converting the ODAs into a form with higher binding affinity for their axonemal binding sites, and hence acting at a key step in the final association of dynein complexes with their docking sites.53"}