PMC:4157146 / 39475-40005 JSONTXT

{"project":"2_test","denotations":[{"id":"25192045-23261303-2045899","span":{"begin":109,"end":111},"obj":"23261303"}],"text":"Considering the similarities in phenotype caused by CCDC114 and CCDC151 mutations with regard to ODA defects,16 we tested for possible interactions between these proteins. Using myc- and FLAG-tagged proteins that were coexpressed in HEK293 cells, we found by coimmunoprecipitation that CCDC151 interacted with CCDC114 (Figure 6C), but not DNAI1, DNAI2, and DNAL1, whose mutations also cause ODA defects (data not shown). We confirmed the reciprocal interaction between CCDC114 and CCDC151 by yeast two-hybrid analysis (Figure S6)."}