PMC:4156421 / 24937-25960 JSONTXT

{"project":"2_test","denotations":[{"id":"25192356-23695349-90446790","span":{"begin":376,"end":378},"obj":"23695349"},{"id":"25192356-19475569-90446791","span":{"begin":530,"end":532},"obj":"19475569"},{"id":"25192356-22651253-90446792","span":{"begin":819,"end":821},"obj":"22651253"},{"id":"25192356-15848724-90446793","span":{"begin":916,"end":918},"obj":"15848724"}],"text":"In addition to offering insight into the pathogenesis of the patient's lung disease, whole genome sequence information may also help to infer prognosis and guide treatment. For example, although this patient unfortunately suffered a rapidly progressive course, in general, the presence of the MUC5B SNP rs35705950 has been recently shown to confer a more favorable prognosis [27]. Other potentially identifiable genetic variants are associated with habitual tobacco use and may be used to help guide smoking cessation strategies [35], thus mitigating at least one controllable risk factor for lung disease. Although, again unfortunately, this patient did not survive to lung transplant, and while there are alternative conventional serological approaches available for tissue typing, whole genome sequence information [36] can be used to precisely match blood types, which is strongly preferred for lung transplant [37], as well as refine HLA typing, which, when matched between donor and recipient, improves outcomes [38]."}

{"project":"PubTator4TogoVar","denotations":[{"id":"27752","span":{"begin":303,"end":313},"obj":"SNP"}],"attributes":[{"id":"A27752","pred":"resolved_to","subj":"27752","obj":"tmVar:rs35705950;VariantGroup:27;RS#:35705950"}],"text":"In addition to offering insight into the pathogenesis of the patient's lung disease, whole genome sequence information may also help to infer prognosis and guide treatment. For example, although this patient unfortunately suffered a rapidly progressive course, in general, the presence of the MUC5B SNP rs35705950 has been recently shown to confer a more favorable prognosis [27]. Other potentially identifiable genetic variants are associated with habitual tobacco use and may be used to help guide smoking cessation strategies [35], thus mitigating at least one controllable risk factor for lung disease. Although, again unfortunately, this patient did not survive to lung transplant, and while there are alternative conventional serological approaches available for tissue typing, whole genome sequence information [36] can be used to precisely match blood types, which is strongly preferred for lung transplant [37], as well as refine HLA typing, which, when matched between donor and recipient, improves outcomes [38]."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"27752","span":{"begin":303,"end":313},"obj":"SNP"},{"id":"T1","span":{"begin":303,"end":313},"obj":"SNP"}],"attributes":[{"id":"A27752","pred":"resolved_to","subj":"27752","obj":"tmVar:rs35705950;VariantGroup:27;RS#:35705950"}],"text":"In addition to offering insight into the pathogenesis of the patient's lung disease, whole genome sequence information may also help to infer prognosis and guide treatment. For example, although this patient unfortunately suffered a rapidly progressive course, in general, the presence of the MUC5B SNP rs35705950 has been recently shown to confer a more favorable prognosis [27]. Other potentially identifiable genetic variants are associated with habitual tobacco use and may be used to help guide smoking cessation strategies [35], thus mitigating at least one controllable risk factor for lung disease. Although, again unfortunately, this patient did not survive to lung transplant, and while there are alternative conventional serological approaches available for tissue typing, whole genome sequence information [36] can be used to precisely match blood types, which is strongly preferred for lung transplant [37], as well as refine HLA typing, which, when matched between donor and recipient, improves outcomes [38]."}