PMC:4143611 / 5041-5779 JSONTXT

{"project":"2_test","denotations":[{"id":"24980037-18413427-63233408","span":{"begin":290,"end":291},"obj":"18413427"},{"id":"24980037-20556520-63233409","span":{"begin":520,"end":521},"obj":"20556520"},{"id":"24980037-15579802-63233410","span":{"begin":523,"end":525},"obj":"15579802"},{"id":"24980037-16474220-63233410","span":{"begin":523,"end":525},"obj":"16474220"},{"id":"24980037-22120352-63233410","span":{"begin":523,"end":525},"obj":"22120352"},{"id":"24980037-18334580-63233411","span":{"begin":645,"end":647},"obj":"18334580"}],"text":"Surgical success is confirmed by subnormal levels of early morning serum cortisol measured within a few days of surgery. Typically, early morning serum cortisol levels of either \u003c2 µg/dL (~50 nmol/L) or \u003c5 µg/dL within a few days after surgery are considered to be indicative of remission [3]. However, reported results are mixed and difficult to interpret since some studies measure basal serum cortisol levels while others use serum cortisol following dexamethasone suppression, or some combination of these measures [5, 11–13]. While clinical practice guidelines provide recommendations for testing in the context of initial diagnosis of CD [10], there is no expert consensus with regard to post-operative testing for surgical success."}