PMC:4143611 / 4474-5040 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4143611","sourcedb":"PMC","sourceid":"4143611","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4143611","text":"Early morning serum cortisol measured between 8 and 10 a.m. is the most commonly utilized measure of immediate remission following surgery. Cortisol secretion normally follows a diurnal pattern with highest levels between 7–9 a.m. that decline to lowest levels around 10–11 p.m. [9]. In patients with CD, the circadian rhythm is aberrant and cortisol levels remain consistently elevated [9, 10]. The goals of pituitary surgery are to extract the ACTH-secreting adenoma and subsequently reduce cortisol levels, leading to improvements in the signs and symptoms of CD.","tracks":[{"project":"2_test","denotations":[{"id":"24980037-9793762-63233405","span":{"begin":280,"end":281},"obj":"9793762"},{"id":"24980037-9793762-63233406","span":{"begin":388,"end":389},"obj":"9793762"},{"id":"24980037-18334580-63233407","span":{"begin":391,"end":393},"obj":"18334580"}],"attributes":[{"subj":"24980037-9793762-63233405","pred":"source","obj":"2_test"},{"subj":"24980037-9793762-63233406","pred":"source","obj":"2_test"},{"subj":"24980037-18334580-63233407","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#eb93ec","default":true}]}]}}