PMC:4143611 / 19942-20436 JSONTXT

{"project":"2_test","denotations":[{"id":"24980037-16868050-63233449","span":{"begin":260,"end":262},"obj":"16868050"},{"id":"24980037-15956075-63233450","span":{"begin":264,"end":266},"obj":"15956075"}],"text":"Surgery is not always curative and some patients will remain hypercortisolemic following TSS. For patients with post-operative serum cortisol \u003e5 µg/dL, immediate repeat surgery, pituitary irradiation, or medical therapy are possible further treatment options [43, 47]. Bilateral adrenalectomy (BLA) can be an alternative in some cases, although there is a risk of the patient developing Nelson’s syndrome; BLA also necessitates lifelong glucocorticoid and mineralocorticoid replacement therapy."}