PMC:4137170 / 4029-5110 JSONTXT

{"project":"2_test","denotations":[{"id":"24928668-14506240-61779593","span":{"begin":411,"end":412},"obj":"14506240"},{"id":"24928668-17965830-61779593","span":{"begin":411,"end":412},"obj":"17965830"},{"id":"24928668-2408340-61779593","span":{"begin":411,"end":412},"obj":"2408340"},{"id":"24928668-11891291-61779593","span":{"begin":411,"end":412},"obj":"11891291"},{"id":"24928668-18507950-61779594","span":{"begin":584,"end":586},"obj":"18507950"},{"id":"24928668-16266768-61779595","span":{"begin":1077,"end":1079},"obj":"16266768"}],"text":"Hyaluronic acid (HA) is one of the major components of the extracellular matrix (ECM) and it is found in all the connective tissues of the body. It is a naturally-derived, linear, high molecular weight polymer with viscoelastic properties [8]. HA is an important element that functions in major biological processes, such as tissue organization, wound healing, angiogenesis, and remodeling in skeletal biology [9–12]. In addition, HA is anionic and therefore capable of forming ionic bonds with cationic growth factors like rhBMPs, which is of significance for clinical applications [13]. In addition, HA is injectable, plays a role as an rhBMP-2 carrier, and has the advantage of requiring no premixing during the surgical operation [14]. Although HA hydrogel has the disadvantage of being too weak to hold mechanical loading, it helps increase loading-bearing prosperity through chemical modification and cross-linking. Other natural polymers with potential use in rhBMP delivery, such as gelatin, dextran, and fibrin, are limited by their insufficient mechanical strengths [15]."}