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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4137170","sourcedb":"PMC","sourceid":"4137170","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4137170","text":"A fairly long time is required for in vivo bone formation, which means that rhBMP-2 needs to be released continuously [27]. The results of the present study showed that a collagen carrier gave an initial burst of released rhBMP-2 in a period of 1 day, whereas the hyaluronic acid-based powder gel released rhBMP-2 continuously for up to 7 days. A previous report on bone healing revealed that the sustained release of growth factor is more favorable than a burst release [28].","tracks":[{"project":"2_test","denotations":[{"id":"24928668-23990717-61779603","span":{"begin":119,"end":121},"obj":"23990717"},{"id":"24928668-22902517-61779604","span":{"begin":472,"end":474},"obj":"22902517"}],"attributes":[{"subj":"24928668-23990717-61779603","pred":"source","obj":"2_test"},{"subj":"24928668-22902517-61779604","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#d8ec93","default":true}]}]}}