PMC:4137170 / 25840-26712 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4137170","sourcedb":"PMC","sourceid":"4137170","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4137170","text":"One limit of this model is that it is unable to provide an environment that is similar to a bone defect site insertion environment. The powder gel-BMP-2 that was implanted into the tibial diaphyseal intramedullary space could not be contained within the defect area and intramedullary blood was infiltrated into BMP-2, which may affect the bone formation [14]. Even though the porous β-TCP microsphere-hyaluronic acid powder gel composite shows osteoconductivity of β-TCP, the rate of osseointegration and new bone formation in this group was similar to the control group. This is possibly because new bone formation did not easily occur in the animal model used in this study. Therefore, in the present study, the new bone formation using the powder gel-BMP-2 composite was significantly high, indicating that the powder gel performed effectively as a carrier of rhBMP-2.","tracks":[]}