PMC:4137170 / 24356-25839 JSONTXT

{"project":"2_test","denotations":[{"id":"24928668-9528003-61779602","span":{"begin":231,"end":233},"obj":"9528003"}],"text":"One role of rhBMP-2 is to promote differentiation of monocytes or mesenchymal stem cells into chondrocytes by promoting their recruitment or proliferation, and then inducing new bone formation through osteoblastic differentiation [26]. Therefore, the number of mesenchymal stem cells in the host is important. From this aspect, the rabbit tibia diaphyseal implantation model used in this study has the advantage of being able to create a similar environment without causing a bone defect because there is no directly contacted osseous tissue around an implant in the marrow space except for the tibial cortical bone. Since the proximal metaphyseal area of the tibia has thin cortical bone and large portion of cancellous bone, a dental implant can be fixed by cancellous bone around near cortex and marrow space although it is not fixed to the far cortex. So, in the present study, the dental implant was not placed in the metaphysis; rather, it was fixed to the near cortex of the diaphysis without contacting the far cortex after countersinking. Thus, it is more difficult to generate newly formed bone when inserting an implant into the tibial diaphysis than when making a bone defect in the mandible or maxilla and then inserting a dental implant. For this reason, this model has the advantage of being able to reduce experimental errors because it is favorable for evaluating the experimental results and the stability of the implant can be well-maintained by the cortical bone."}