PMC:4137170 / 1874-2762 JSONTXT

{"project":"2_test","denotations":[{"id":"24928668-20009601-61779589","span":{"begin":529,"end":530},"obj":"20009601"},{"id":"24928668-23285317-61779589","span":{"begin":529,"end":530},"obj":"23285317"},{"id":"24928668-19767691-61779589","span":{"begin":529,"end":530},"obj":"19767691"}],"text":"The screw type metal implant is widely used in orthopedic, dental, plastic, and maxillofacial surgery. As the number of elderly people has increased, the rate of dental implantation has risen and surgery for patients that have poor bone stock has also been increased. Osseointegration of a metal implant is greatly influenced by the quality of the host bone, and it can be negatively affected by previous radiation therapy or infection, smoking, bone defects, osteoporosis, etc., thereby endangering the survival of the implant [1–4]. For patients with bone defect or poor bone stock, successful dental implant surgery could increase the bone quantity and quality of the implantation site, thereby improving the osseointegration. Therefore, methods to strengthen osseointegration that include implantation of a growth factor to promote bone healing are currently of considerable interest."}