PMC:4137170 / 15696-16796 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4137170","sourcedb":"PMC","sourceid":"4137170","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4137170","text":"Physical properties of the HA-based powder gel\nThe prepared HA-based powder gel was uniformly rehydrated (Fig. 3a). A SEM image of cross-linked and freeze-dried HA-based hydrogel is presented in Fig 3b. The HA-based powder gel showed a swelling ratio of 671.4 % in PBS (Fig. 3c), which means that, in this study, the powder gel has sufficient capacity to load the BMP-2 solution. The HA-based powder gel was mixed with β-TCP spherical powder using the in situ mixing process described above.\nFig. 3 a SEM images of cross-linked and freeze-dried HA-based hydrogel; b Images of the hydrated HA-based powder-gel; c Swelling ratio of the HA-based powder-gel\n\nrhBMP-2 release results\nThe collagen sponge was completely decomposed in 1 day and the impregnated rhBMP-2 was fully released within 1 day (Fig. 4). In contrast, the hyaluronic acid-based powder gel composite showed slow release compared to the collagen sponge, and the amount of rhBMP-2 released was less than 20 % of the total after 7 days.\nFig. 4 In vitro release of BMP-2 (A: Hyaluronic acid (HA)-based powder-gel; Control: collagen sponge)","divisions":[{"label":"title","span":{"begin":0,"end":46}},{"label":"p","span":{"begin":47,"end":654}},{"label":"figure","span":{"begin":492,"end":654}},{"label":"label","span":{"begin":492,"end":498}},{"label":"caption","span":{"begin":499,"end":654}},{"label":"p","span":{"begin":499,"end":654}},{"label":"title","span":{"begin":656,"end":679}},{"label":"label","span":{"begin":999,"end":1005}}],"tracks":[]}