PMC:4134656 / 9410-10337 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4134656","sourcedb":"PMC","sourceid":"4134656","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4134656","text":"High dose pulse corticosteroids (methyl prednisolone 30 mg/kg/day infused over 1 hour daily for 3 days) may be useful in IH which need immediate therapeutic response (e.g. large peri-ocular IH with complete visual axis occlusion or large airway haemangioma with respiratory difficulty). Usually three or more monthly doses are required followed by shorter oral steroid regimen. Pope et al. in their randomized controlled trial of oral versus high dose pulse steroids in 20 children with problematic IH concluded that oral corticosteroids offer more clinical and biological benefit than pulsed steroids. However, patients in the oral steroid group had a higher frequency of side effects such as hypertension (18% vs. 13%), abnormal cortisol levels (78% vs. 60%) and growth retardation.[21] Figure 1a and b show good response (of hemangioma on the scalp) to steroids in one of our cases. The child also developed Cushingoid face.","tracks":[{"project":"2_test","denotations":[{"id":"25136206-17485449-58659541","span":{"begin":785,"end":787},"obj":"17485449"}],"attributes":[{"subj":"25136206-17485449-58659541","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9393ec","default":true}]}]}}