PMC:4134656 / 31775-33743
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4134656","sourcedb":"PMC","sourceid":"4134656","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4134656","text":"Pulsed Dye Laser (PDL)\nPDL has been used successfully for the treatment of ulcerated IH, which reduces the pain and promotes healing.[58] It is also used to remove the residual telangiectasia. However, the use of PDL in uncomplicated IH is controversial. There are non-randomized studies which claim that PDL is better than the wait-and-watch policy.[5960] In a large prospective RCT by Batta et al., 121 children with uncomplicated early haemangiomas were assigned to PDL (585 nm) treatment or observation.[61] At the end of 1 year, there was no significant differences between the 2 groups (60 in PDL group, 61 in observation group) in terms of complete clearance or residual features. The adverse effects were significantly more in the PDL group which led the authors to conclude that PDL is no better than observation in uncomplicated superficial IH.[61] In another recent prospective RCT on 22 infants, the intervention group was treated with PDL (595 nm). The authors did not observe any difference in echo depth or surface area at 1 year between the intervention (n = 11) and observation groups (n = 11). However, the cosmetic outcome was significantly better in the PDL group.[62] In a comparative study between traditional PDL (585 nm) and long PDL (LPDL; 595 nm), the authors found that a similar number of infants achieved complete clearance or showed minimal residual signs at 1 year of age (14/26, 54% in PDL group vs. 17/26, 65% in LPDL group; P = 0.4), although the infants in LPDL group suffered significantly less side-effects like hypo- or hyperpigmentation, textural changes and the period of maximal proliferation was also significantly shortened (106 days in LPDL versus 177 days in PDL group).[63]\nThere is no consensus on the optimal settings of PDL and selection of type of haemangiomas suitable for treatment with laser. Currently, the use of PDL is confined to the treatment of ulceration and post-involution erythema and telangiectasias.[64]","divisions":[{"label":"title","span":{"begin":0,"end":22}},{"label":"p","span":{"begin":23,"end":1719}}],"tracks":[{"project":"2_test","denotations":[{"id":"25136206-12873458-58659623","span":{"begin":134,"end":136},"obj":"12873458"},{"id":"25136206-19889007-58659624","span":{"begin":351,"end":353},"obj":"19889007"},{"id":"25136206-8733375-58659625","span":{"begin":351,"end":355},"obj":"8733375"},{"id":"25136206-12241656-58659626","span":{"begin":508,"end":510},"obj":"12241656"},{"id":"25136206-12241656-58659627","span":{"begin":855,"end":857},"obj":"12241656"},{"id":"25136206-23279058-58659628","span":{"begin":1185,"end":1187},"obj":"23279058"},{"id":"25136206-16374781-58659629","span":{"begin":1716,"end":1718},"obj":"16374781"},{"id":"25136206-9420551-58659630","span":{"begin":1965,"end":1967},"obj":"9420551"}],"attributes":[{"subj":"25136206-12873458-58659623","pred":"source","obj":"2_test"},{"subj":"25136206-19889007-58659624","pred":"source","obj":"2_test"},{"subj":"25136206-8733375-58659625","pred":"source","obj":"2_test"},{"subj":"25136206-12241656-58659626","pred":"source","obj":"2_test"},{"subj":"25136206-12241656-58659627","pred":"source","obj":"2_test"},{"subj":"25136206-23279058-58659628","pred":"source","obj":"2_test"},{"subj":"25136206-16374781-58659629","pred":"source","obj":"2_test"},{"subj":"25136206-9420551-58659630","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#d1ec93","default":true}]}]}}