PMC:4134656 / 30101-30861 JSONTXT

{"project":"2_test","denotations":[{"id":"25136206-23627540-58659621","span":{"begin":757,"end":759},"obj":"23627540"}],"text":"Imiquimod, an immune response modifier with anti-angiogenic and pro-apoptotic properties, has been used in the treatment of superficial IH. Imiquimod 5% cream is applied on alternate days at bed time and left for 8 hours. It is washed with mild soap the next morning. The duration of therapy is about 4 months. Severe inflammatory reactions may occur with application of imiquimod. Qiu et al. studied the efficacy and safety of imiquimod in their retrospective comparative study of imiquimod versus timolol in superficial proliferative IH. They found that the efficacy of imiquimod was comparable with timolol. However, inflammatory changes were seen in 13 of 20 (65%) cases in the imiquimod group while none of cases in the timolol group had side effects.[56]"}