PMC:4134656 / 27558-28569
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4134656","sourcedb":"PMC","sourceid":"4134656","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4134656","text":"Timolol is a non-selective β blocker which is used for increased intra-ocular pressure. In 2010, Guo and Ni first reported the clinical response to timolol 0.5% solution in a 4-month-old infant who had a thin haemangioma plaque on the upper eyelid.[48] Subsequently, several pilot studies and case series have shown its clinical efficacy.[49505152] It has been mostly used for localized, non-ulcerated superficial IHs. Chan et al. found timolol to be more effective for lesions with a mean diameter of \u003c11.3 mm (i.e. 100 mm3 in volume) as compared to larger lesions.[53] It is to be applied two times a day. One drop of timolol maleate (0.5%) contains 0.25 mg of the drug.[53] It is recommended to apply 1 drop of the gel two times a day. Some authors recommend 3-4 times application.[52] Timolol does not penetrate deeply and hence it is not useful in deep haemangiomas.[52] Treatment is more effective in the proliferative phase than in the involution phase, and also, plaques respond better than nodules.[53]","tracks":[{"project":"2_test","denotations":[{"id":"25136206-20142555-58659608","span":{"begin":249,"end":251},"obj":"20142555"},{"id":"25136206-22731954-58659609","span":{"begin":339,"end":341},"obj":"22731954"},{"id":"25136206-22417222-58659610","span":{"begin":339,"end":343},"obj":"22417222"},{"id":"25136206-22471694-58659611","span":{"begin":339,"end":345},"obj":"22471694"},{"id":"25136206-22179543-58659612","span":{"begin":339,"end":347},"obj":"22179543"},{"id":"25136206-23650294-58659613","span":{"begin":567,"end":569},"obj":"23650294"},{"id":"25136206-23650294-58659614","span":{"begin":673,"end":675},"obj":"23650294"},{"id":"25136206-22179543-58659615","span":{"begin":785,"end":787},"obj":"22179543"},{"id":"25136206-22179543-58659616","span":{"begin":872,"end":874},"obj":"22179543"},{"id":"25136206-23650294-58659617","span":{"begin":1008,"end":1010},"obj":"23650294"}],"attributes":[{"subj":"25136206-20142555-58659608","pred":"source","obj":"2_test"},{"subj":"25136206-22731954-58659609","pred":"source","obj":"2_test"},{"subj":"25136206-22417222-58659610","pred":"source","obj":"2_test"},{"subj":"25136206-22471694-58659611","pred":"source","obj":"2_test"},{"subj":"25136206-22179543-58659612","pred":"source","obj":"2_test"},{"subj":"25136206-23650294-58659613","pred":"source","obj":"2_test"},{"subj":"25136206-23650294-58659614","pred":"source","obj":"2_test"},{"subj":"25136206-22179543-58659615","pred":"source","obj":"2_test"},{"subj":"25136206-22179543-58659616","pred":"source","obj":"2_test"},{"subj":"25136206-23650294-58659617","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#cd93ec","default":true}]}]}}