PMC:4134656 / 23169-24790 JSONTXT

{"project":"2_test","denotations":[{"id":"25136206-23266923-58659600","span":{"begin":506,"end":507},"obj":"23266923"},{"id":"25136206-23278381-58659601","span":{"begin":968,"end":970},"obj":"23278381"},{"id":"25136206-23405852-58659602","span":{"begin":1500,"end":1502},"obj":"23405852"},{"id":"25136206-23405852-58659603","span":{"begin":1618,"end":1620},"obj":"23405852"}],"text":"Propranolol, being a beta blocker, has a negative inotropic and chronotropic effect on the heart. The effect on the pulse rate and BP can be seen around 2 hours after the oral dose. The most serious side effect is hypoglycaemia especially in infants \u003c 3 months of age with poor feeding. The other possible side effects include pulmonary symptoms, sleep disturbances, somnolence, cold extremities and gastrointestinal (GI) complaints. These adverse reactions are not serious, reversible and dose-dependent.[7] In 174 patients treated for IH from a single centre, 108 children (62.1%) had 1 or more adverse reactions. The two most common problems were cold extremities (63, 36.2%) and nocturnal restlessness (39, 22.5%). Twenty-eight children (16.1%) were less active during the day. Lower blood pressure was observed in 6 cases (3.4%). Sixteen patients (3.2%) had pulmonary symptoms, out of which 9 needed treatment. In 12 children (6.9%), GI complaints were recorded.[31] In another meta-analysis of 39 studies in 1189 children, 371 cases had adverse reactions. The most common adverse event was sleep changes, which included insomnia, nightmares, night restlessness, fatigue and sleep disturbance in 136 cases followed by acrocyanosis in 61 children. There were 41 reports of GI problem like diarrhoea and gastroesophageal reflux. Respiratory adverse events were seen in 35 patients. Hypotension and bradycardia were seen in 39 and 8 cases, respectively. Hypoglycaemia was reported only in 4 cases.[27] The other side effects reported in the literature include irritability, profuse sweating and temporary hypotonia.[27]"}